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EC number: 618-251-5 | CAS number: 89182-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation in vivo (Rabbit-NZW, GLP, OECD TG 404): not irritating to the skin
[Bayer AG, Report No. PH-18456, 1989-10-23]
Eye irritation in vivo (Rabbit-NZW, GLP, OECD TG 405): not irritating to the eye
[Bayer AG, Report No. PH-18456, 1989-10-23]
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- July 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well reported GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 405
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 females
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Executive summary:
500 mg of the test substance was semi-occlusively applied to the shaved intact skin of 3 female rabbits for an exposure period of 4 h. Evaluation of skin irritation was made according to Draize.
In this skin irritation study N-Formylaminosorbit was not irritating to the skin.
Reference
Results of the study:
Irritant Effects (Scores) | ||||||||||
24 h | 48 h | 72 h | Mean scores | |||||||
animal | erythema | edema | erythema | edema | erythema | edema | erythema | edema | ||
1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||
3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- July 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well reported GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 404
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 7 d
- Number of animals or in vitro replicates:
- 3 females
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 0
- Executive summary:
100 mg of the test substance was administered into the conjunctival sac of one eye of female rabbits with rinsing 24 h after instillation.
Evaluation of eye irritation was made according to Draize.
According to the classification criteria N-Formylaminosorbit is not irritating to eyes.
Reference
Results of the study
Irritant Effects (Score) | |||||||
Animal | 1 h | 24 h | 48 h | 72 h | 7 d | Mean scores | |
1 | Cornea Opacity | 0 | 0 | 0 | 0 | 0 | 0.0 |
Cornea Area | 0 | 0 | 0 | 0 | 0 | ||
Fluorescein Intensity | - | 0 | - | - | - | ||
Fluorescein Area | - | 0 | - | - | - | ||
Iris | 0 | 0 | 0 | 0 | 0 | ||
Conjunctivae Redness | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Conjunctivae Swelling | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Aqueous humour | 0 | 0 | 0 | 0 | 0 | ||
Discharge | 1 | 0 | 0 | 0 | 0 | ||
2 | Cornea Opacity | 0 | 0 | 0 | 0 | 0 | 0.0 |
Cornea Area | 0 | 0 | 0 | 0 | 0 | ||
Fluorescein Intensity | - | 0 | - | - | - | ||
Fluorescein Area | - | 0 | - | - | - | ||
Iris | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Conjunctivae Redness | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Conjunctivae Swelling | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Aqueous humour | 0 | 0 | 0 | 0 | 0 | ||
Discharge | 1 | 0 | 0 | 0 | 0 | ||
3 | Cornea Opacity | 0 | 0 | 0 | 0 | 0 | 0.0 |
Cornea Area | 0 | 0 | 0 | 0 | 0 | ||
Fluorescein Intensity | - | 0 | - | - | - | ||
Fluorescein Area | - | 0 | - | - | - | ||
Iris | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Conjunctivae Redness | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Conjunctivae Swelling | 0 | 0 | 0 | 0 | 0 | 0.0 | |
Aqueous humor | 0 | 0 | 0 | 0 | 0 | ||
Discharge | 1 | 0 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the skin irritation test in all 3 animals no signs of skin irritation could be observed.
In the eye irritation test discharge (grade 1) 1 h after instillation was the only finding in all 3 animals. No signs of eye irritation could be observed after 24, 48 and 72 h.
Justification for selection of skin irritation / corrosion endpoint:
only one study available
Justification for selection of eye irritation endpoint:
only one study available
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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