Registration Dossier
Registration Dossier
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EC number: 938-702-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
One reliable (Klimisch 1) short-term toxicity study to fish was available for Cyclohexanol, 4-C11-12-alkyl, branched. The short-term toxicity of Cyclohexanol, 4-C11-12-alkyl, branched to fathead minnows (Pimephales promelas) was reported by Brougher et al., (2012) in an OECD 203 guideline and GLP compliant study.
Fathead minnows (Pimephales promelas) were exposed for 96 hours under static-renewal conditions to five nominal water accommodated fraction (WAF) loading rates of Cyclohexanol, 4-C11-12-alkyl, branched ranging from 6.3 to 100 mg/L. Based on WAF loading rates, the 96 hour EL50 value was >100 mg/L, the highest concentration tested. Fathead minnows exposed to Cyclohexanol, 4-C11-12-alkyl, branched at concentrations ≤100 mg/L appeared normal with no mortality or overt signs of toxicity. The 96 hour no-mortality level and the NOELR were both 100 mg/L.
One reliable (Klimisch 1) short-term toxicity study to invertebrates was available for Cyclohexanol, 4-C11-12-alkyl, branched. The short-term toxicity of Cyclohexanol, 4-C11-12-alkyl, branched to Daphnia magna was reported by Brougher et al., (2012) in an OECD 202 guideline and GLP compliant study.
The cladoceran, Daphnia magna, was exposed for 48 hours under static conditions to five nominal water accommodated fraction (WAF) loading rates of Cyclohexanol, 4 -C11 -12 -alkyl, branched ranging from 6.3 to 100 mg/L. Based on WAF loading rates, the 48-hour EL50 value was > 100 mg/L, the highest concentration tested. Daphnids exposed to the test substance at concentrations ≤ 100 mg/L appeared normal with no immobility or overt signs of toxicity. The 48-hour no-immobility level and the NOELR were both 100 mg/L.
One reliable (Klimisch 1) toxicity study to aquatic algae was available for Cyclohexanol, 4-C11-12-alkyl, branched. The toxicity of Cyclohexanol, 4-C11-12-alkyl, branched to freshwater alga Preudokirchneriella subcapitata was reported by Arnie et al., (2012) in a GLP compliant OECD 201 guideline and EPA OCSPP 850.4500 study. Algae were exposed to the test substance in nominal concentrations based on WAF loading rates for 96 hours, resulting in a 72-hr ErL50 of >100 mg/L.
The toxicity of Cyclohexanol, 4 -C11 -12 -alkyl, branched to the fresh water green alga Pseudokirchneriella subcapitata over a 96 -hour exposure period was tested according to the OECD Guidelines for Testing of Chemicals, Guideline 201: "Freshwater Alga and Cyanobacteria, Growth Inhibition Test", adopted 23 March 2006. The fresh water green alga Pseudokirchneriella subcapitata, was exposed for 96 hours under static conditions to five nominal water accommodated fraction (WAF) loading rates of Cyclohexanol, 4-C11-12-alkyl, branched, ranging from 6.3 to 100 mg/L. Effects were evaluated based on yield and growth rate. The 72-hours EyL50 and ErL50 values were > 100 mg/L. The 72-hour NOELR, based on effects on growth rate was 50 mg/L.
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