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Diss Factsheets
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EC number: 204-552-5 | CAS number: 122-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- publication
- Title:
- Acute evaluation of triethyl phosphite.
- Author:
- Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
- Year:
- 1 992
- Bibliographic source:
- Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Materials and methods
- Principles of method if other than guideline:
- Ten Fischer 344 rats per sex and dose were exposed to an aerosol for 6 h. Exposure MMAD´s were between 1.6 and 3.5 μm. Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC. Aerosol measurement was performed by a cascade impactor. Clinical signs, body weight gain and LC50 were reported. No details on doses were given.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethylphosphite
- IUPAC Name:
- Triethylphosphite
- Details on test material:
- Purity: no data.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age: 9-11 weeks.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: undiluted
- Details on inhalation exposure:
- Exposure MMAD´s were between 1.6 and 3.5 μm.
Aerosol concentrations were produced using a Solosphere (R) nebulizer and were analysed by GC.
Aerosol measurement was performed by a cascade impactor. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatographic analysis
- Duration of exposure:
- 6 h
- Concentrations:
- No data.
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight gain
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 11.62 mg/L air
- Based on:
- test mat.
- 95% CL:
- 10.08 - 12.76
- Exp. duration:
- 6 h
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 11.06 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Remarks on result:
- other: Confidence limits could not be calculated due to reversals in mortality curve.
- Mortality:
- No details were reported. Most deaths occured within 24 hours following treatment.
- Clinical signs:
- other: Signs of toxic stress included eye and upper respiratory irritation, salivation and rapid, shallow breathing. Surviving animals appeared normal to conclusion of observation period.
- Body weight:
- Subnormal weight gain of survivors during the 14-days observation period.
- Gross pathology:
- Dead animals: restricted to diffuse lung congestion.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.