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EC number: 620-056-5 | CAS number: 874195-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Version / remarks:
- 2000
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA Test Guidelines, OPPTS 835.1230, Adsorption/Desorption (Batch Equilibrium), 2008
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese MAFF New Test Guidelines, Part 2-9-10, 2001
- Qualifier:
- according to guideline
- Guideline:
- other: Canada PMRA, Guidelines for Registration of Pesticides, Environmental Chemistry and Fate, 1987
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Arbeit, Gesundheit und Soziales des Landes Nordrhein-Westfalen
- Type of method:
- batch equilibrium method
- Media:
- soil
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Vapour pressure: 6.4 x 10-E6 Pa at 20°C
- Water solubility:
41 mg/L (distilled water, pH 6.8) at 20°C
36 mg/L (buffer, pH 4) at 20°C
33 mg/L (buffer, pH 7) at 20°C
34 mg/L (buffer, pH 9) at 20°C
- log Pow: 1.5 - 1.6
- pKa: no pKa in water at 1.1 < pH < 10.4
- Stability of test material:
pH 4: < 10% degradation after 30 days at 25°C
pH 7: < 15% degradation after 30 days at 25°C
pH 9: DT50 < 3 days at 25°C - Radiolabelling:
- yes
- Test temperature:
- 20.0°C - 20.3°C
- Details on study design: HPLC method:
- EQUIPMENT
- HPLC system: Agilent 1100 Series chromatography workstation with UVdetector (VWD, Agilent 1100 Series) operated at 254 nm and radioactivity detector (Ramona Star, Raytest, Straubenhardt, Germany) and MS spectrometer
- 14C Detector: Ramona Star (Raytest), equipped with a 370 μL glass solid phase scintillator flow cell
- Software: Data acquisition and HPLC control: Gina Star (Raytest)
- Column: Purospher Star RP-18e, 250 x 4.6 mm, 5 μm (Merck)
- Guard column: Purospher Star RP-18e, 4 x 4 mm, 5 μm (Merck)
MOBILE PHASES
- Type: Gradient method
- Flow rate: 1.0 mL/min
- Temp.: 40°C
- Injection volume: 10 – 500 μL
- Eluent A: 1 % formic acid in water
- Eluent B: 1 % formic acid in acetonitrile
REFERENCE SUBSTANCES
- Identity: Non-Radiolabeled AE 1887196, (1.4 mg) was dissolved in 1.4 mL of acetonitrile/water
EVALUATION
Calculation of the Freundlich constant and related KOC was performed according to OECD 106 - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Four different soils at five concentrations in the range of about 0.01 to 1.0 mg/L
- Sampling interval: At equilibrium (after 24 hours)
- Sample storage before analysis: The samples were analyzed immediately after preparation or directly after sampling. - Details on matrix:
- COLLECTION AND STORAGE
- Geographic location:
#1: Laacher Hof AXXa, Monheim, Germany (GPS coordinates: N 51° 04.6' E 006° 53.5')
#2: Dollendorf II, Blankenheim, Germany (GPS coordinates: N 50° 22.9' E 006° 43.0')
#3: Laacher Hof Wurmwiese, Monheim, Germany (GPS coordinates: N 51° 04.9' E 006° 55.3')
#4: Hoefchen Am Hohenseh 4a, Burscheid, Germany (GPS coordinates: N 51° 04.0' E 007° 06.3')
- Storage conditions: Refrigerated at ≤ 8°C for < 2 months
- Soil preparation: Sieved to ≤ 2 mm, air dried
PROPERTIES
#1: Laacher Hof AXXa
- Soil texture: Sandy Loam
- % sand: 75
- % silt: 19
- % clay: 6
- Soil taxonomic classification: Sandy, mixed, mesic, Typic Cambudolls
- Soil classification system: USDA
- pH: 6.4
- Organic carbon (%): 2.1
- CEC (meq/100 g): 9.6
- Water Holding Capacity 0.33 bar (%): 12
- Bulk density (g/cm3): 1.21
#2: Dollendorf II
- Soil texture: Loam
- % sand: 35
- % silt: 41
- % clay: 24
- pH: 7.2
- Organic carbon (%): 4.7
- CEC (meq/100 g): 21.2
- Water Holding Capacity 0.33 bar (%): 32.5
- Bulk density (g/cm3): 0.96
#3: Laacher Hof Wurmwiese
- Soil texture: Sandy Loam
- % sand: 55
- % silt: 29
- % clay: 16
- Soil taxonomic classification: Loamy, mixed, mesic, Typic Argudalfs
- Soil classification system: USDA
- pH: 5.5
- Organic carbon (%): 2.0
- CEC (meq/100 g): 10.7
- Water Holding Capacity 0.33 bar (%): 16.9
- Bulk density (g/cm3): 1.15
#4: Hoefchen Am Hohenseh 4a
- Soil texture: Silt Loam
- % sand: 25
- % silt: 61
- % clay: 14
- Soil taxonomic classification: Loamy, mixed, mesic, Typic Argudalfs
- Soil classification system: USDA
- pH: 6.6
- Organic carbon (%): 2.3
- CEC (meq/100 g): 14.5
- Water Holding Capacity 0.33 bar (%):
- Bulk density (g/cm3): 1.06 - Details on test conditions:
- TEST SYSTEM
- Type, size and further details on reaction vessel: Centrifuge tubes with screw cap, material Teflon®, volume 42 mL
- Agitation: Test vessels were shaken by an mechanical overhead shaker, 30 ± 2 rpm
- Temperature: 20 ± 2°C, walk-in climatic chamber, recorded by a Thermistor connected to a data logger (Squirrel 1200, Grant Inst. Ltd).
- Equilibration time: 24 hours (adsorption), 24 hours (desorption)
- Method of preparation of test solution: 5g (#1, #3, #4) or 2g (#2) soil was weighed into the centrifuge tubes and aqueous 0.01 M CaCl2 solution
containing 50 mg/L HgCl2 was added to a water volume of 18 mL (corrected for soil moisture). After pre-equilibration by shaking overnight, 2 mL of the respective application solution was added to a final volume of 20 mL.
- Number of reaction vessels/concentration: Duplicates with five concentrations for each soil (0.01, 0.03, 0.10, 0.29, and 1.14 mg/L)
- Desorption test: The supernatants were decanted, weighed and replaced by a corresponding volume of aqueous 0.01 M CaCl2 solution containing 50 mg/L HgCl2. - Duration:
- 24 h
- Initial conc. measured:
- 0.01 - 1.14 other: mg/L
- Temp.:
- 20 °C
- Duration:
- 24 h
- Temp.:
- 20 °C
- Computational methods:
- - Adsorption and desorption coefficients (Kd): Calculations according to OECD Guideline 106.
- Freundlich adsorption and desorption coefficients: Calculations according to OECD Guideline 106.
- Slope of Freundlich adsorption/desorption isotherms: Calculations according to OECD Guideline 106.
- Adsorption coefficient per organic carbon (Koc): Based on the Freundlich Kf value the respective Freundlich Koc value was determined. - Type:
- Koc
- Value:
- 101.9
- Temp.:
- 20 °C
- Remarks on result:
- other: soil #1
- Type:
- Koc
- Value:
- 100.3
- Temp.:
- 20 °C
- Remarks on result:
- other: soil #2
- Type:
- Koc
- Value:
- 85.8
- Temp.:
- 20 °C
- Remarks on result:
- other: soil #3
- Type:
- Koc
- Value:
- 104.9
- Temp.:
- 20 °C
- Remarks on result:
- other: soil #4
- Adsorption and desorption constants:
- The adsorption constants KF(ads) of AE 1887196 for the four test soils calculated based on the Freundlich isotherms ranged from 1.715 to 4.712 mL/g (mean: 2.745 mL/g).
The desorption constants KF(des) of AE 1887196 were approx. 2 times higher than the respective adsorption constants indicating a stronger binding of the test item once adsorbed to the soils. - Recovery of test material:
- The test item was stable in the course of the study. The parental mass balance for the adsorption/desorption phase was > 94 % of the applied radioactivity. No major degradation product was observed.
- Details on results (Batch equilibrium method):
- No significant correlation between pH and adsorption can be seen for the Koc of the investigated soils.
Reference
Table 1: Summary of adsorption in soil
KF[mL/g] |
l/n |
R2 |
KOC [mL/g] |
|
Soil #1 |
2.140 |
0.9292 |
0.9971 |
101.9 |
Soil #2 |
4.712 |
0.9081 |
0.9993 |
100.3 |
Soil #3 |
1.715 |
0.9197 |
0.9996 |
85.8 |
Soil #4 |
2.412 |
0.9247 |
0.9989 |
104.9 |
Mean |
2.745 |
0.9204 |
0.9987 |
98.2 |
Table 2: Summary of desorption in soil
KF[mL/g] |
l/n |
R2 |
KOC [mL/g] |
|
Soil #1 |
4.677 |
0.9687 |
0.9984 |
222.7 |
Soil #2 |
9.788 |
0.9422 |
0.9995 |
208.3 |
Soil #3 |
3.740 |
0.9485 |
0.9991 |
187.0 |
Soil #4 |
4.535 |
0.9334 |
0.9990 |
197.2 |
Mean |
5.685 |
0.9482 |
0.9990 |
203.8 |
Description of key information
logKoc = 1.9-2.0 (OECD 106)
Triafamone has a low adsorption potential to soil and sediment.
Key value for chemical safety assessment
Additional information
The adsorption / desorption of triafamone (CAS No. 874195-61-6) was studied in four soils in batch equilibrium experiments according to OECD guideline 106 under GLP conditions (Eckermann and Koenig, 2012). The studies were conducted in the dark in the laboratory with test concentrations of 0.01, 0.03, 0.10, 0.29 and 1.14 mg/L for 48 hours at 20.1 °C. The four representative soils are sampled from agricultural use areas and cover a wide range of physico-chemical properties. Radio labeled [phenyl-UL-14C] triafamone was used as test substance and the amounts of test item and its degradation products were determined by liquid scintillation counting (LSC). The complete material balances found in the test demonstrated that there was no significant loss of radioactivity from the test systems or during sample processing. The adsorption parameters were calculated using the Freundlich adsorption isotherm. The resulting Koc values for the adsorption of triafamone ranged for the four soils between 85.8 and 104.9 (logKoc =1.9-2.0).
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