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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: only as secondary citation available: guideline study and GLP

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalene-1,5-diol
EC Number:
201-487-4
EC Name:
Naphthalene-1,5-diol
Cas Number:
83-56-7
Molecular formula:
C10H8O2
IUPAC Name:
naphthalene-1,5-diol
Test material form:
other: solid
Details on test material:
content 99.9 % batch no.820211/01

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: the untreated eye served as control
Amount / concentration applied:
the equivalent of 0.1 ml (39.7 mg)
Duration of treatment / exposure:
single application
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
3 males
Details on study design:
the equivalent of 0.1 ml of the undiluted test substance was instilled into the concunctival sax of one eye of each test animal. The eye lids were held together for about one second to avoid loss of test substance. Eye irritant reactions were assessed approximately 1, 24, 48 and 72 hours and 7 and 14 days after instillation. on day 2, after fluorescein examination, the treated eye was rinsed with warm tap water. The untreated eye seved as control.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
other: mean animal 1
Time point:
other: 24-72 hours
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 14 days
Irritation parameter:
chemosis score
Basis:
other: mean animal 1
Time point:
other: 24-72 hours
Score:
1.7
Max. score:
4
Reversibility:
fully reversible within: 7 days
Irritation parameter:
conjunctivae score
Basis:
other: mean of animal 2 and mean of animal 3
Time point:
other: 24-72 hours
Score:
2.7
Max. score:
4
Reversibility:
fully reversible within: 14 days
Irritation parameter:
chemosis score
Basis:
other: mean of animal 2 and mean of animal 3
Time point:
other: 24-72 hours
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 72 hours
Irritant / corrosive response data:
Conjunctival redness was observed in 3 animals at 1 hour to 7 days.
Chemosis was observed in 3 animals at 1, 24, and 48 hours and in 1 animal also at 72 hours
Mean value of eye irritation scores (24-72 hours) for each animal were for
redness: 3.0, 2.7, 2.7
chemosis: 1.7, 1.0, 1.0
No iridial irritation or conrneal opacity was observed

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Executive summary:

1,5 -naphthalenediol was tested in rabbits for eye irritation according to OECD TG 405. Under conditions of this study the test substance was irritant to the rabbit eye. The effects were fully reversible within 14 days..