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EC number: 620-174-7 | CAS number: 1079184-43-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information is included in the detailed justification for read-across in the endpoint summary “Aquatic toxicity”.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar ecotoxicological properties because they share structural similarities with common functional groups: quaternary amines, esters, and fatty acid chains with comparable length and degree of saturation. Furthermore, they are expected to hydrolyse to a comparable product (amine backbone) and common products (long chain fatty acids). This prediction is supported by ecotoxicological data on the substances themselves.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Further information is included in the detailed justification for read-across in the endpoint summary “Aquatic toxicity”.
3. ANALOGUE APPROACH JUSTIFICATION
Further information is included in the detailed justification for read-across in the endpoint summary “Aquatic toxicity”.
4. DATA MATRIX
Further information is included in the detailed justification for read-across in the endpoint summary “Aquatic toxicity”. - Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.54 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% ci 0.10-2.9 mg/L
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.2 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- growth rate
- Remarks on result:
- other: 95% ci 0.24-6.0 mg/L
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 0.49 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- biomass
- Remarks on result:
- other: 95% ci 0.22-1.0 mg/L
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.95 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- act. ingr.
- Basis for effect:
- biomass
- Remarks on result:
- other: 95% ci 0.44-2.1 mg/L
- Conclusions:
- The NOEC, EC10 and EC50 of MDIPA Esterquat C18 unsatd. to algae in the presence of humic acid based on growth rate were 0.39, 0.54 (95% c.i. 0.10-2.9 mg/L) and 1.2 mg/L (95% c.i. 0.24-6.0 mg/L), respectively.
The NOEC, EC10 and EC50 based on based on yield were 0.39, 0.49 (95% c.i. 0.22-1.0 mg/L) and 0.95 mg/L (95% c.i. 0.44-2.1 mg/L), respectively.
Reference
Description of key information
OECD guideline 201, Pseudokirchneriella subcapitata, static, GLP, RL1, in the presence of 4 mg/L humic acid; read across MDIPA Esterquat C18 unsatd
72 h NOEC (growth rate) = 0.39 mg/mL, 72 h ErC10 = 0.54 mg/L (95% c.i. 0.10-2.9 mg/L), 72 h ErC50 = 1.2 mg/L (95% c.i. 0.24-6.0 mg/L);
72 h NOEC (biomass) = 0.39 mg a.i./mL, 72 h EyC10 = 0.49 mg/L (95% c.i. 0.22-1.0 mg/L), 72 h EyC50 = 0.95 mg/L (95% c.i. 0.44-2.1 mg/L)
OECD guideline 201, Pseudokirchneriella subcapitata, static, GLP, RL1, in the presence of 4 mg/L humic acid; read across MDIPA Esterquat C16-18 and 18 unsatd.:
72 h NOEC (growth rate) = 2.7 mg/mL, 72 h ErC10 = 3.2 (95% c.i. 2.5-4.1 mg/L), 72 h ErC50 = 8.1 mg/L (95% c.i. 6.4-10 mg/L);
72 h NOEC (biomass) = 0.91 mg a.i./mL, 72 h EyC10 = 1.3 (95% c.i. 0.45-3.7 mg/L), 72 h EyC50 = 4.4 mg/L (95% c.i. 1.6-12 mg/L)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1.2 mg/L
- EC10 or NOEC for freshwater algae:
- 0.54 mg/L
Additional information
In a 96 h algal toxicity study conducted according to a modification of EPA OTS 797.1050 (Algal Toxicity, Tiers I and II),Selenastrum capricornutumwas exposed MDEA-Esterquat C16-18 and C18 unsatd. at nominal concentrations of 0, 2, 4, 8, 16 and 32 mg/L under static conditions. The 96 hr ErC50 value was 2.9 mg/L ( 95% confidence limit <2.0 - 4.2 mg/L; nominal).
This toxicity study is classified as not reliable and does not satisfy the guideline requirements for aquatic toxicity to algae (validity Klimisch 3). Deviations were: no analytical determination of test substance, river water used instead of algal media, and cell counts only done on controls at 0 h timepoint.
However, reliable toxicity studies in freshwater algae are available for the structurally similar source substances MDIPA-Esterquat C16-18 and C18 unsatd. and MDIPA-Esterquat C18 unsatd.. A justification for read-across is given in the general endpoint summary Aquatic toxicity.
In a 72 hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata, strain NIVA CHL 1 were exposed toMDIPA Esterquat C18 unsatd. at nominal concentrations of 0 (control), 0.10, 0.32, 1.0, 3.2 and 10 mg/L, corresponding to measured (TWA) 0.042, 0.14, 0.39, 1.3 and 1.7 mg/L in the presence of 4 mg/L humic acidunder static conditions in accordance with OECD guideline 201 (adopted March 23, 2006; Annex 5 corrected 28 July 2011).
Microscopic observations revealed no abnormalities.
The NOEC, EC10 and EC50 based on growth rate were 0.39, 0.54 (95% c.i. 0.10-2.9 mg/L) and 1.2 mg/L (95% c.i. 0.24-6.0 mg/L), respectively.
The NOEC, EC10 and EC50 based on based on yield were 0.39, 0.49 (95% c.i. 0.22-1.0 mg/L) and 0.95 mg/L (95% c.i. 0.44-2.1 mg/L), respectively.
All effect levels are given based onmeasured (TWA) concentrations.
In a 72 hour acute toxicity study, the cultures of Pseudokirchneriella subcapitata, strain NIVA CHL 1 were exposed to MDIPA-Esterquat C16-18 and C18 unsatd. at nominal concentrations of 0 (control), 0.25, 0.80, 2.5, 8.0 and 25 mg/L, corresponding to measured (TWA) 0.29, 0.91, 2.7, 6.2 and 25 mg/L in the presence of 4 mg/L humic (<2 mg/L DOC) acidunder static conditions in accordance with OECD guideline 201 (adopted March 23, 2006; Annex 5 corrected 28 July 2011).
Microscopic observations revealed no abnormalities.
The NOEC, EC10 and EC50 based on growth rate were 2.7, 3.2 (95% c.i. 2.5-4.1 mg/L) and 8.1 mg/L (95% c.i. 6.4-10 mg/L), respectively.
The NOEC, EC10 and EC50 based on based on yield were 0.91, 1.3 (95% c.i. 0.45-3.7 mg/L) and 4.4 mg/L (95% c.i. 1.6-12 mg/L), respectively.
All effect levels are given based onmeasured (TWA) concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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