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Diss Factsheets
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EC number: 213-235-0 | CAS number: 931-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No guideline study. Limited information on methods.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Based on results from MEC (methylethylenecarbonate)
- GLP compliance:
- no
Test material
- Reference substance name:
- methylenecarbonate
- IUPAC Name:
- methylenecarbonate
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 0.6
- Temp.:
- 52 °C
- Hydrolysis rate constant:
- 0.001 min-1
- DT50:
- 27 h
- Type:
- second order
- Remarks on result:
- other: MEC expressed as l/mol/min
- pH:
- 8.2
- Temp.:
- 0
- Hydrolysis rate constant:
- 0.001 min-1
- DT50:
- 33 h
- Type:
- second order
- Remarks on result:
- other: MEC
Any other information on results incl. tables
Hydrolysis of jeffsol glycerine carbonate leads to CO2 and diol as hydrolysis end products. Hydrolysis rate were reported from MEC. MEC contains a hydroxygroup and this hydroxy group is removed from the site of hydrolysis by at least 3 atoms, making MEC a suitable surrogate for jeffsol GC. The second-order hydrolysis rate contact of MEC is 6.14E-04 L/mol/min, cooresonding to a half life of 17h at 52°C. Based on the general rule of doubling the half-life per decade of temparture decrease, the half-life at 20°C was estimated at 220h. Based on the OECD guideline 111, these surrogate predicts that jeffsol GC would be hydrolytically unstable at acidic pH. This also applies at basic pH, because the rate of hydrolysis of the surrogate is faster a basic pH (33h at 0°, corresponding to 8h at 20°C). No hydrolysis half-life data was found under neutral conditions. However, under initially neutral unbuffered conditions, the hydrolysis of Jeffsol GC would cause the pH become more acidic due to the hydrolysis product CO2. Therefore, given the above hydrolysis half-life of the surrogate MEC under acidic conditions (9 days at 20C°), it is likely that the half-life of jeffsol GC under initially neutral unbuffered conditions would be comparable to the MEC half-life under acidic conditions.
Applicant's summary and conclusion
- Conclusions:
- Based on the surrogate data, it was concluded that Jeffsol GC would be hydrolytically unstable (OECD, 1993, guideline 111) at acidic and basic pH. Due to the acidity caused by the hydrolysis product CO2, jeffsol GC would likely to be hydrolytically unstable under initially neutral unbuffered conditions.
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