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EC number: 247-988-1 | CAS number: 26762-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diisopropylbenzene hydroperoxide
- EC Number:
- 247-988-1
- EC Name:
- Diisopropylbenzene hydroperoxide
- Cas Number:
- 26762-93-6
- Molecular formula:
- C12H18O2
- IUPAC Name:
- reaction mass of 1-(3-isopropylphenyl)-1-methylethyl hydroperoxide and 1-(4-isopropylphenyl)-1-methylethyl hydroperoxide
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: small white russian Chbb-SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Karl Thomae GmbH, Biberach
- Age at study initiation: no data
- Weight at study initiation: 2.4 kg
- Housing: alone in stainless steel cage
- Diet (e.g. ad libitum): "K4 Alleindiät für Kaninchen" ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C
- Humidity (%): 60%
- Air changes (per hr): 15/h
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 14/04/1989 To: 18/04/1989
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 cm3 - Duration of treatment / exposure:
- 4h, 1h and 3min
- Observation period:
- 1 , 24, 48 and 72 hours and 6 days after removal of the dressing
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm2
- % coverage: no data
- Type of wrap if used: elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): softly with warm water
- Time after start of exposure: 3 min, 1 hour, and 4hours
SCORING SYSTEM: according to OECD guideline 404
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4-h exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Remarks:
- 4-h exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Right after the patch removing following the 4 h exposure, signs of necrose could be observed, parchementy-like effect at 24h and 48h, and dark-brown scrab after 72h and 6d.
After a period of 1Hr, necrosis also occurred but not after an exposure time of 3 Min
- Other effects:
- no other effects were observed.
Any other information on results incl. tables
no additionnal data
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Under the conditions of the test, the test substance would be classified as corrosive category 1B according to the criteria of the CLP Regulation (1272/2008).
- Executive summary:
In a dermal irritation study conducted according to OECD 404 guideline in compliance with GLP, one healthy adult rabbit of the Whiter Russian strain was exposed to 0.5 ml of DIHP, diisopropylbenze hydroperoxide at 55% in diisopropylbenzene, at one skin site on the back. Test site was covered with a dressing held in place for 4 hours, 1 hour and 3 minutes. The skin reactions were assessed at 1, 24, 48, 72 hours and 6 days after dressing removal.
Application of DIHP resulted in erythema and oedema after 1h and 4h application time. This could be observed after 1h observation period at a sore of 4/4 for both erythema and oedema and could still be observed at this same score after 6 days observation. Additionnally, necrosis could be observed over the 6 days too. After an exposure time of 3 min, no necrosis was observed.
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