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EC number: 235-185-9 | CAS number: 12125-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- May 1995 - June 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study comply with the Principles of GLP OECD and was conducted in accordance with EPA OPP 81-4 guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-3 (Acute inhalation toxicity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Remarks:
- GLP statement included
- Limit test:
- no
Test material
- Reference substance name:
- NaF
- IUPAC Name:
- NaF
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Composite NaF
- Molecular formula (if other than submission substance): NaF
- Molecular weight (if other than submission substance):
- Smiles notation (if other than submission substance):
- InChl (if other than submission substance):
- Structural formula attached as image file (if other than submission substance): see Fig.
- Substance type:
- Physical state: white powder
- Analytical purity:
- Impurities (identity and concentrations):
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: 199-7-4
- Expiration date of the lot/batch:
- Radiochemical purity (if radiolabelling):
- Specific activity (if radiolabelling):
- Locations of the label (if radiolabelling):
- Expiration date of radiochemical substance (if radiolabelling):
- Stability under test conditions:
- Storage condition of test material:
- Other:
- Date received: April 27, 1995
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0.52, 1.02 and 1.98 mg/L
- No. of animals per sex per dose:
- five males and five females per group
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed at least daily for signs of gross toxicity and mortality; bodyweights recorded just prior to exposure (day 0) and on days 7 and 14 (i.e. termination) or after death
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Mortality at 0.52 mg/L: Total 2/10 (i.e. Males 0/5; Females 2/5)
Mortality at 1.02 mg/L: Total 5/10 (i.e. Males 1/5; Females 4/5)
Mortality at 1.98 mg/L: Total 8/10 (i.e. Males 3/5; Females 5/5) - Clinical signs:
- other: All animals, irrespective of their exposure level, displayed clinical signs such as: ocular and nasal discharge facial staining ano-genital staining abnormal respiration abnormal posture pilo-erection hypoactivity. Survivors from all exposure groups reco
- Body weight:
- Some surviving animals lost bodyweight through day 7, however all gained weight over the entire 14 -day observation period.
- Gross pathology:
- - Gross necropsy of decedents:
discoloration of the lungs, gastro-intestinal tract, liver and spleen; edema of the lungs; distention of the gastro-intestinal tract; fluid in the stomach and/or rigor mortis.
- Gross necropsy of survivors from all groups was generally unremarkable. Two survivors from the group exposed to 0.52 mg/L exhibited dark red foci on the lungs.
Applicant's summary and conclusion
- Conclusions:
- An acute inhalation toxicity study was conducted with rats to determine the toxicity via inhalation for NaF and the defined LC50 value is 1.00 mg/L.
- Executive summary:
An acute inhalation toxicity study was conducted with rats to determine the toxicity via inhalation for NaF.
After establishing the desired generation procedures during pre-test trials, 30 healthy rats were selected and equally distributed into three exposure groups of five males and five females each. Exposure values were 0.52, 1.02 and 1.98 mg/L and each test group was exposed for four hours. Chamber concentration and particle size distribution were determined periodically during each exposure.
The animals were observed for signs of gross toxicity and mortality at least daily for 14 days. Bodyweights were recorded just prior to exposure (day 0) and again on days 7 and 14 (i.e. termination) or after death. Necropsies were performed on all animals.
The mortality at each exposure level is provided below:
Exposure levelmg/L Mortality Males Females Total 0.52 0/5 2/5 2/10 1.02 1/5 4/5 5/10 1.98 3/5 5/5 8/10 Following exposure all animals, irrespective of their exposure level, displayed clinical signs such as: ocular and nasal discharge, facial staining, ano-genital staining, abnormal respiration, abnormal posture, pilo-erection and hypoactivity. Survivors from all exposure groups recovered from these symptoms by day 12 of the study. Although some surviving animals lost bodyweight through day 7, all gained weight over the entire 14 -day observation period. Gross necropsy of the decedents revealed discoloration of the lungs, gastro-intestinal tract, liver and spleen, edema of the lungs, distention of the gastro-intestinal tract, fluid in the stomach and/or rigor mortis. Gross necropsy of the survivors from all groups was generally unremarkable. Two survivors from the group exposed to 0.52 mg/L exhibited dark red foci on the lungs.
Based on the results, the acute inhalation toxicity study defined LC50 of NaF is 1.00 mg/L.
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