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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 26, 2012 to October 24, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (DIN 9408) with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO DIS 9408 (Ultimate Aerobic Biodegradability - Method by Determining the Oxygen Demand in a Closed Respirometer)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- EC Number:
- 213-485-0
- EC Name:
- 3-acetoxymethylen-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cas Number:
- 957-68-6
- Molecular formula:
- C10H12N2O5S
- IUPAC Name:
- (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name: 7-Aminocephalosporansäure
Lot: B146988
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial, adapted
- Details on inoculum:
- Source and type: Cleaned activated adapted sludge from the industrial sewage plant ARA of the Industriepark Höchst
Used amount: 13.7 mL/L sludge suspension
Content of solid: 2.2 g/L (dry substance)
Content in the end testing volume: 30 g/L (dry substance)
Acclimatization status: Not acclimatized to the test item and reference substance - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
- Based on:
- other: calculated from TOC and Purity of the test item
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Testing temperature: 22.9 - 23.4°C
pH value: 7.3 - 7.6
Preparation volume: 0.365 L in 1L-Bottles with magnetic stirrers, connected to the respirometer unit
Analytics of the Degradability: Measurement of the biochemical O2-requirement by measuring the pressure differences in aclosed respirometer cell
Analytics of the elimination: Determination of the CSB in O2/L
Control preparations:
reference substance: 100mg/L in dilution water
abiotic control: test preparation without inokulum, with addition of 2x100 mg/L HgCl2 during test performance
Inhibition control: 100 mg/L reference substance and 100 mg/L test item in dilution water
Reference substance
- Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 100 mg/l in dilution water
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 30
- Sampling time:
- 28 d
- Details on results:
- Due to the elimination caused by the abiotic control (elimination 21% after 3 days, 28% after 28 days) no evaluation of the biological degradability of the test item can be stated.
For the results of the elimination the test item can be evaluated as moderately eliminable under the test conditions.
The elimination rate DThSB was 30% after 28 days, the CSB-elimination came up to 31% after 28 days.
BOD5 / COD results
- Results with reference substance:
- The degradability of the reference substance was >60% after 14 days.
The rate of degradability of the inhibition control was >40%.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: 7-ACA is moderately eliminable under the test conditions
- Conclusions:
- Due to the elimination caused by the abiotic control (elimination 21% after 3 days, 28% after 28 days) no evaluation of the biological degradability of the test item can be stated.
For the results of the elimination the test item can be evaluated as moderately eliminable under the test conditions.
The elimination rate DThSB was 30% after 28 days, the CSB-elimination came up to 31% after 28 days.
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