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Diss Factsheets
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EC number: 223-989-2 | CAS number: 4156-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption: The test material is expected to be readily bio-available at the portal of entry and also in systemic circulation.
Distribution: Ready systemic distribution beyond the portal of entry is expected. The substance is not expected to accumulate in fatty tissues.
Metabolism: Significant metabolism is expected due to the intended reactivity of the chlorinated triazine moiety with nucleophils like water or proteins. The main expected reaction is an inactivation by hydrolysis.
Excretion: The test material as well as the expected hydrolysis products are soluble in water, ready excretion in mammals is expected via the kidney.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The test material has the chemical structure of sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)-amino]-benzene-sulphonate. The pH-Value of aqueous solutions is almost neutral. Due to the presence of a sulfonic acid salt moiety the substance is polar and well soluble in water. The partition coefficient was determined as -0.48, which means that the substance is about 10 times as soluble in water compared to octanol. The substance is used in leather tanning as a tanning agent und textile fiber treatment. The mechanism of this action most probably is based on the ability to bind covalently to fibers and crosslink proteins.
The material is corrosive in vivo to mucous membranes.
Absorption: The test material is soluble in water and octanol. Via its local corrosive effects the substance can destroy the natural barriers of mucous membranes. Therefore it is expected to be readily bio-available at the portal of entry and also in systemic circulation. This notion is supported by the observed systemic toxicity in several test systems.
Distribution: Due to the good solubility of the substance, ready systemic distribution beyond the portal of entry is expected. The substance is not expected to accumulate in fatty tissues.
Metabolism: The test material has a molecular weight about 414 Dalton and is easily soluble at physiologic pH. Significant metabolism is expected due to the intended reactivity of the chlorinated triazine moiety with nucleophils like water or proteins. The main expected reaction is an inactivation by hydrolysis.
Excretion: The test material as well as the expected hydrolysis products are soluble in water, ready excretion in mammals is expected via the kidney.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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