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Diss Factsheets
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EC number: 270-194-1 | CAS number: 68412-52-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Read-Across of experimental data from analogius compounds based on expert judgement.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1555-62-0
- EC Number:
- 605-014-6
- Cas Number:
- 1555-62-0
- IUPAC Name:
- 1555-62-0
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Species Wistar rat
Strain Hoe: WISKf(SPF71)
Origin Hoechst Aktiengesellschaft, Kastengrund,SPF breeding colony
Body weight at start of study
male animals mean = 178 g (= 100 %)
s = ±7g
min = 171 g (- 3.9 %)
max = 186 g (+ 4.5 %)
n = 5
female animals mean' = 182 9 (= 100 %)
s = ±4g
min = 178 9 (- 2.2 %)
max = 189 9 (+ 3.8 %)
n = 5
Age at the start of the study male animals approximately 7 weeks
female animals approximately 8 weeks
Randomization Randomization schemes 94.0358 and 94.0359
Animal maintenance in fUlly air-conditioned rooms in macrolon cages (type 4) on soft wood granulate in groups of 5 animals
Room temperature 22 ± 3°C
Relative humidity 50 ± 20 %
Lighting time 12 hours daily
Acclimatization at least one day (breeding at identical conditions)
Food ssniff'! R/M-H (V 1534), ad libitum
Withdrawal of food from about 16 hours before to 3 - 4 hours after treatment
Water tap water in plastic bottles, ad libitum
Animal identification fur marking with KMn04 and cage numbering
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 20% suspension in sesam oil
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- The prepared test substance was administered by gavage to fasted animals at the stated dosage. The observation period following treatment lasted for 14 days. Symptoms were recorded twice every day (in the morning and in the afternoon), on weekends and public holidays only once. During this time the animals were weighed weekly. At the end of the observation period the animals were killed by carbon dioxide asphyxiation, dissected and examined for macroscopically visible changes.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the whole study.
- Clinical signs:
- other: The following clinical signs were observed after the application of C12-Sternnitril in males and females: decreased spontaneous activity, squatting posture, stilted gait and diarrhea. Additionally, the females showed stupor, bristled coat, sunken flanks,
- Gross pathology:
- No macroscopically visible changes observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results obtained in this OECD401 study the median lethal dose value (LD50) of N,N-Di-(2-cyanoethyl)-dodecylnitrilfor the male and female Wistar rat is greater than 2000 mg/kg body weight.
- Executive summary:
Based on the results obtained in this OECD401 study the median lethal dose value (LD50) of N,N-Di-(2-cyanoethyl)-dodecylnitrilfor the male and female Wistar rat is greater than 2000 mg/kg body weight.
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