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EC number: 470-720-1 | CAS number: 189253-72-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guidelance study under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- GLP compliance:
- yes
- Remarks:
- statement
Test material
- Reference substance name:
- -
- EC Number:
- 470-720-1
- EC Name:
- -
- Cas Number:
- 189253-72-3
- Molecular formula:
- C10H25N3O
- IUPAC Name:
- N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine
- Details on test material:
- N-[2-[2-(dimethylamine) ethoxy] ethyl]-N-methyl-I ,3-
Batch 19902-1
Purity >92%
Expiry date 31 October 2006
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Charles River Deutschland, Kisslegg, Germany
- Age at study initiation: 6 weeks
- Weight at study initiation: 1.0 Kg
- Diet :Standard laboratory rabbit diet (Charles River Breeding and Maintenance Diet for Rabbits, Altromin, Lage, Germany) approx. 100 g. per day.
- Water :Free access to tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): temperature of 21.0 ± 3.0
- Humidity (%):30-70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light):12 hours artificial fluorescent light and 12 hours darkness per day
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: dorsal fur was clipped with electric clippers
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of the substance/ pure material
- Duration of treatment / exposure:
- There were 3 sites prepared on the single animal. The time of exposure was 3 mins-1 hr - 1 hr.
- Observation period:
- Immediately and 1 h after removal of the patch.
- Number of animals:
- 1
- Details on study design:
- Test animal received of 0.5 ml of the test substance to the intact, clipped skin of one flank using a Metalline patch# of 2x3 cm. The patch was mounted on Micropore tape', which was wrapped around the abdomen and secured with Coban elastic bandage.The dressing was removed 3 minutes after application
Since no signs of severe skin reactions (i.e. necrosis or corrosion) were observed and it was considered that exposure could be continued humanely, two samples of 0.5 ml of the test substance were then applied to separate skin-sites on the intact, clipped skin of the same animal, using an identical procedure and one sample per dressing. One of the dressings was removed after a 1-hour exposure.
Since signs of severe skin reactions (necrosis) were observed after 1 hour of exposure, the remaining dressing was removed immediately. After skin reading, the study was terminated. No further testing was performed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 3 min
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 3 min
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other: assessed immediately after removal of patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Assessed immediately after removal of the patch
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other: Assessed 1 hr after removal of the patch
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Assessed 1 h after the removal of the patch
- Other effects:
- Dark discoloration and signs of necrosis were observed immediately after the removal of the 1 h patch.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Corrosive > 3 min and < 1 h exposure Criteria used for interpretation of results: EU
- Conclusions:
- Substance was found to be corrosive > 3 min and < 1 h exposure and it is classified as category 1B.
- Executive summary:
One rabbit was exposed to three samples of 0.5 ml of N42-[2 -(DlMETHYLAMINE)ETHOXY]ETHYL)-N-METHYL- ,3-PROPANEDIAMINE applied to separate skin-sites on intact, clipped skin using a semi-occlusive dressing. The exposure periods were 3 minutes, 1 hour and 1 hour, respectively. Skin reactions were assessed immediately after removal of the dressings andlor after 1 hour. Since severe skin reactions were noted after one hour of exposure, the animal was sacrificed for humane reasons.
Three minutes exposure to Nj2-12-(DIMETHYLAMINE)ETHOXY]ETHYL)-N-METHYL- ,3 -PROPANEDIAMINE resulted in very slight erythema and no oedema in the treated skin-areas of the rabbit, noted immediately after removal of the dressing and after 1 hour.
One hour of exposure resulted in severe erythema and brown discoloration (signs of necrosis) covering the entire application site and seen immediately after removal of the dressings.
Severe necrosis was observed during the observation period, indicating that corrosion of the skin had occurred by dermal application of N42-12-(DIMETHYLAMINE)ETHOXY]ETHYL)-NMETHYL- 1,3-PROPANEDIAMINE to the intact rabbit skin after one hour of exposure.
Based on these results and according to the:
- OECD Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances (OECD, 1998), N42-12 -(DIMETHYLAMINE)ETHOXV]ETHYL}-N-METHYL-1,3-PROPANEDIAMINE should be
classified as : skin corrosive (Class 1 B).
- EC criteria for classification and labeling requirements for dangerous substances and preparations (Council Directive 67/548lEEC), N42-[2-(DIMETHYLAMINE)ETHOXY]ETHYL)-N-METHYL-1,3-PROPANEDIAMINE should be labeled as: causes burns (R 34).
- criteria for transport and packaging labeling as specified in Accord Europken Relatif (ADR) ), Appendix A, Class 8, N-(2-[2-(DIMETHYLAMlNE)ETHOXY]ETHYL)-N-METHYL-1,3 -PROPANEDIAMINE should be classified in packaging group I1 (irritating substances).
- criteria for transport and packaging labeling as specified in International Maritime Dangerous Goods code, Vol. IV, General introduction to Class 8 - Corrosives section 2.1, Amdt. 28-96. N42-12-(DIMETHYLAMlNE)ETHOXV]ETHYL)-N-METHYL- ,3-PROPANEDIAMINE should be classified in packaging group I1 (preparations and substances presenting medium
danger).
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