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Diss Factsheets
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EC number: 930-010-9 | CAS number: 461432-25-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 18 June 2014 and 22 August 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- Principles of method if other than guideline:
- ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances via Cascade Impactor
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- other: Fibre Length and Diameter Distribution of Chemical Substances
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- Too few particles were of a size less than 10.0 μm to allow determination of mass median aerodynamic diameter
- Key result
- Percentile:
- other: Too few particles were of a size less than 10.0 μm to allow determination of mass median aerodynamic diameter
- Remarks on result:
- not determinable because of methodological limitations
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 15.6 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- < 0.001 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- < 0.001 %
- Conclusions:
- Particle size data acquired for the test item is shown below:
Percentage of test item with an inhalable particle size <100 μm = 15.6% (method: sieve)
Percentage of test item with a thoracic particle size <10.0 μm = <9.8x 10^-3 % (method: cascade impactor)
Percentage of test item with a respirable particle size <5.5 μm = < 7.8 x 10^-3 % (method: cascade impactor) - Executive summary:
The general physico-chemical properties of BMS-587172-01 have been determined. The results are summarized below:
Particle Size Distribution.
Particle size data was acquired, using a procedure designed to be compatible with the European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’, 2002. The results are as follows:
Particle size data acquired for the test item is shown below:
Percentage of test item with an inhalable particle size <100 μm = 15.6% (method: sieve)
Percentage of test item with a thoracic particle size <10.0 μm = <9.8x 10^-3 % (method: cascade impactor)
Percentage of test item with a respirable particle size <5.5 μm = < 7.8 x 10^-3 % (method: cascade impactor)
Reference
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement | Result |
Mass of test item transferred to sieve | 11.54 g |
Mass of test item passed through sieve | 1.80 g |
Percentage of test item less than 100 μm | 15.60% |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Collection Stage | Particle Size Range Collected (μm) | Collected Mass (g) | ||
Determination 1 | Determination 2 | Determination 3 | ||
Artificial throat | n/a | 0.08 | 0.03 | 0.05 |
Cup 1 | >10.0 | 2.4313 | 2.502 | 2.53 |
Cup 2 | 5.5 to 10.0 | 0.0000 | 0.0000 | 0.0000 |
Cup 3 | 2.4 to 5.5 | 0.0000 | 0.0000 | 0.0000 |
Cup 4 | 1.61 to 2.4 | 0.0000 | 0.0000 | 0.0000 |
Cup 5 | 0.307 to 1.61 | 0.0000 | 0.0000 | 0.0000 |
Final Filter | <0.307 | 0.0000 | 0.0000 | 0.0000 |
Total mass of collected test item | 2.5113 | 2.5113 | 2.532 | 2.58 |
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle Size Cut Points (μm) | Cumulative Mass (g) | Cumulative Percentage (%) | ||||
Determination 1 | Determination 2 | Determination 3 | Determination 1 | Determination 2 | Determination 3 | |
<10.0 | < 0.00025 | < 0.00025 | < 0.00025 | < 9.8 x 10-3 | < 9.9 x 10-3 | < 9.7 x 10-3 |
<5.5 | < 0.0002 | < 0.0002 | < 0.0002 | < 7.8 x 10-3 | < 7.9 x 10-3 | < 7.8 x 10-3 |
<2.4 | < 0.00015 | < 0.00015 | < 0.00015 | < 5.9 x 10-3 | < 5.9 x 10-3 | < 5.8 x 10-3 |
<1.61 | < 0.0001 | < 0.0001 | < 0.0001 | < 3.9 x 10-3 | < 3.9 x 10-3 | < 3.9 x 10-3 |
<0.307 | < 0.00005 | < 0.00005 | < 0.00005 | < 2.0 x 10-3 | < 2.0 x 10-3 | < 1.9 x 10-3 |
Mean cumulative percentage with a particle size less than 10.0 μm : < 9.8 x 10-3%
Mean cumulative percentage with a particle size less than 5.5 μm : < 7.8 x 10-3%
Discussion
Too few particles were of a size less than 10.0 μm to allow accurate assessment of the mass median aerodynamic diameter.
Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 10 minutes then sampled from the top, middle and bottom.
As there was no measurable quantity of test item in the sample cups the result has been calculated as a limit value based on the accuracy of the balance used.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Description of key information
Particle size data acquired for the test item:
Percentage of test item with an inhalable particle size <100 μm = 15.6% (method: sieve)
Percentage of test item with a thoracic particle size <10.0 μm = <9.8x 10^-3 % (method: cascade impactor)
Percentage of test item with a respirable particle size <5.5 μm = < 7.8 x 10^-3 % (method: cascade impactor)
Additional information
Particle size data was acquired, using a procedure designed to be compatible with the European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’, 2002.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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