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EC number: 407-330-8 | CAS number: 61571-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
The substance was tested for its sensitizing effect on the skin of the guinea pig in the Maximization Test according to Magnusson and Kligman (1969). The test substance concentrations for the main test were selected based on the results of a pretest. For the intradermal induction, 0.1 ml of 5 % test material in vehicle was injected. For the epicutaneous induction a 75 % dilution and for the epicutaneous challenge a 50 % dilution in olive oil DAB 9, was applied to the skin. The study was performed using 2 control groups and 1 test group. The intradermal induction was performed on day 0 and the epicutaneous induction on day 8. A challenge was carried out day 21 and a second challenge additional 8 days later. After the application of the test substance preparation in Freund's adjuvant/0.9% aqueous NaCl-solution (1 :1) necrotic skin changes in addition to distinct edema could be observed in the test animals. The control animals injected with olive oil DAB 9 (vehicle) showed distinct erythema. After the percutaneous induction necrotic skin changes (caused by the intradermal induction) in addition to distinct edema were observed in the test animals. The animals of control group 1 and 2 which were applied with olive oil DAB 9 (vehicle) exhibited incrustation, partially open (caused by the intradermal induction) in addition to distinct erythema and edema. After the first challenge with the 50 % test substance preparation in olive oil DAB 9 (48 hours after the beginning of application) distinct erythema in addition to slight edema could be observed in one out of 20 test animals. 3 out of 20 test animals showed slight erythema. The animals of control group one did not show any skin reactions at the 48- and 72 hour - readings. After the second challenge with the 50 % test substance preparation in olive oil DAB 9 (48 hours after the beginning of application) in one out of 20 test animals distinct erythema was observed. 3 out of 20 test animals showed slight erythema. The animals of control group one and two did not show any skin reactions at the 48- and 72 hour - readings. Olive oil DAB 9 applied as a vehicle caused distinct erythema in one animal and slight erythema in another animal of the test group 48 hours after the first challenge. The control animals did not show any skin reaction neither after the first, nor after the second challenge (48- and 72 hour - readings).
Migrated from Short description of key information:
Guinea pig: not sensitizing (OECD 406, BASF AG 1990)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Actually, there is no information available to cover this endpoint.
Migrated from Short description of key information:
Actually, there is no information available to cover this endpoint.
Justification for classification or non-classification
Based on the test result of the Guinea Pig Maximization Test and applying the criteria of Annex VI/II D of the Council Directive of July 29, 1983 for the 5th Amendment of the Directive 67/548 EEC (= 83/467 EEC)) for test evaluation, the test substance does not fulfill the criteria of being a skin sensitizer and therefore needs not to be classified according to EU or GHS criteria. There is no indication given that cyclopentyl chloroformate is a sensitizer of the respiratory tract.
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