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Diss Factsheets
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EC number: 200-453-6 | CAS number: 60-09-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 4-Aminoazobenzene. BUA-Stoffbericht 217
- Author:
- Beratergremium für Altstoffe (BUA)
- Year:
- 1 998
- Bibliographic source:
- BUA der Gesellschaft dt. Chemiker, S. Hirzel Wissenschaftliche Verlagsgesellschaft, Stuttgart
- Reference Type:
- publication
- Title:
- Sensitization induced by patch testing
- Author:
- Agrup G
- Year:
- 1 968
- Bibliographic source:
- Br J Dermatol. 80: pp:631-634
- Reference Type:
- publication
- Title:
- Dermatitis from an azo-dye in industrial Ieather protective shoes
- Author:
- Ancona A, Serviere L, Trejo A, Monroy F
- Year:
- 1 982
- Bibliographic source:
- Contact Dermatitis 8: pp. 220-221
- Reference Type:
- publication
- Title:
- Contact dermatitis from a stamp-ink of the German post ofiice
- Author:
- Braun WPH
- Year:
- 1 975
- Bibliographic source:
- Contact Dermatitis 1, 189
- Reference Type:
- publication
- Title:
- Cosmetic intolerance
- Author:
- Broeckx W, et al.
- Year:
- 1 987
- Bibliographic source:
- Contact Dermatitis 16: 189-194
- Reference Type:
- publication
- Title:
- Contact dermatitis of the feet
- Author:
- Correia S, Brandao FM
- Year:
- 1 986
- Bibliographic source:
- Dermatosen Beruf Umwelt 34: 102-105
- Reference Type:
- publication
- Title:
- Textile dye dermatitis
- Author:
- Dooms-Goossens A
- Year:
- 1 992
- Bibliographic source:
- Contact Dermatitis 27: 321-323
- Reference Type:
- publication
- Title:
- Investigations of group allergies to aromatic aminocompounds [Untersuchungen zur Gruppenallergie bei aromatischen Amino- Verbindungen]
- Author:
- Düngernann H, Borelli S
- Year:
- 1 966
- Bibliographic source:
- Berufs-Dermatosen 14,281-295
- Reference Type:
- publication
- Title:
- Patch test results with a shoewear screening tray in 119 patients, 1977-1980
- Author:
- Lynde CW, Warshawski L, Mitchell JC
- Year:
- 1 982
- Bibliographic source:
- Contact Dermatitis 8: 423-425
- Reference Type:
- publication
- Title:
- Standard patch tests in agncultural workers.
- Author:
- Garcia-Perez A, et al.
- Year:
- 1 984
- Bibliographic source:
- Contact Dermatitis 10: 151-153
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- not specified
Test material
- Reference substance name:
- 4-aminoazobenzene
- EC Number:
- 200-453-6
- EC Name:
- 4-aminoazobenzene
- Cas Number:
- 60-09-3
- Molecular formula:
- C12H11N3
- IUPAC Name:
- 4-[(E)-2-phenyldiazen-1-yl]aniline
Constituent 1
Results and discussion
Any other information on results incl. tables
Numerous patient cohorts and occupationally exposed persons clearly reacted positively to 4-Aminoazobenzene in concentrations of 0.25 - 2 % in vaseline or methylethylketone in the epicutaneous test. Moreover, several case descriptions exist in which positive reactions by 4-Aminoazobenzene in concentrations of 0.25 - 5 % could be triggered in individuals with dermatitis.
(IUCLID, 1996: Arnold et al., 1995; Bruynzeel et al., 1983; Degreef et al., 1985; Dooms-Goossens et al., 1987; Foussereau et al., 1986; Goh and Kozuka, 1986; Hausen, 1994; Hjorth and Rothenborg, 1967; Katoh et al., 1986; Manzini et al., 1991; Matsunaga et al., 1990; Prens et al., 1986; Roeleveld and van Ketel, 1975, 1976; Saha et al., 1993; Schubert et al., 1987; Schulz, 1962; Seidenari et al., 1997; Thierbach et al., 1992; Thune, 1984; Uter et al., 1993, 1996).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.