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EC number: 225-591-4 | CAS number: 4948-28-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-03-12 to 1979-05-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- See "Principles of method other than guideline"
- Principles of method if other than guideline:
- - Principle of test: Acute dermal toxicity test in rabbits
- Short description of test conditions: A single dermal treatment was given to 3 male and 3 female albino rabbits. The skin of three rabbits was abraded, the remaining animal's skin remained intact. The test side was occluded for 24 hours. Animals were observed for sign of toxicity for 14 days and then subjected to gross pathology. No detailed description of environmental conditions, dose preparation, vehicle identity and clinical signs are available. Body weights were not recorded during the study. Times of death were not described.
- Parameters analysed / observed: Mortality, gross pathology - GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (1α,2α,5α)-2,2,6-trimethylbicyclo[3.1.1]heptan-2-ol
- EC Number:
- 225-591-4
- EC Name:
- (1α,2α,5α)-2,2,6-trimethylbicyclo[3.1.1]heptan-2-ol
- Cas Number:
- 4948-28-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (1R,2S,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: Yes
- Rationale for use of males: Both males and females were used
- Age at study initiation: 3-4 months
- Weight at study initiation: 1.76 - 2.32 kg
- Housing: In galvanized cages with indirect bedding
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: At least 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Temperature-controlled room
- Humidity (%): Not specified
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From day 0 to day 15
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing: The remaining test item was wiped off the skin after 24 hours
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- One single dose of 5000 mg/kg bw
- No. of animals per sex per dose:
- 3 animals per sex were treated with a single dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for pharmacologic activity and drug toxicity 1, 3, 6 and 24 hours after treatment and daily thereafter. Body weights were recorded at the beginning of the study and after the 14-day observation period.
- Necropsy of survivors performed: Yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None of the animals died within the treatment and post-treatment period.
- Clinical signs:
- other: No clinical signs observed
- Gross pathology:
- The internal organs and superficial examination appeared normal.
- Other findings:
- In two male animals with abraded skin, small scab has formed and detached.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study in male and female rabbits, all animals survived after a single dose of 5000 mg/kg bw. The LD50 is thus >5000 mg/kg bw.
- Executive summary:
In a GLP compliant acute dermal toxicity study in 3 male and 3 female New Zealand white rabbits, the test item was applied at a single dose of 5000 mg/kg bw by occlusive administration to abraded (2 males and 1 female) and non-abraded (1 male, 2 females) skin. The test side was occluded for 24 hours. After the treatment period, the occlusive wrap and all remaining test item was removed. Animals were observed for pharmacologic activity and drug toxicity 1, 3, 6 and 24 hours after treatment and daily thereafter for a total of 14 days. Non-survivors and and animals surviving the 14-day observation period were subjected to gross necropsy. No deaths, clinical signs or changes in body weight gain were observed. Thus, the LD50 was found to be >5000 mg/kg bw.
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