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EC number: 421-750-9 | CAS number: 57280-22-5 TRIOXABICYCLOOCTAN; TRIOXABICYCLOOCTANE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- February 1987
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- EC Number:
- 421-750-9
- EC Name:
- 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
- Cas Number:
- 57280-22-5
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Mol:WIST
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard Breeding Centre Ltd, Ejby, DK-4623 Ll. Skensved.
- Age at study initiation: 5-6 weeks
- Weight at study initiation: 144-151 g
- Fasting period before study: 18 h
- Housing: The rats were individually ear-tagged and kept in Macrolone cages Type III (42 x 26 x 15 cm) 2 or 3 to a cage,· males and females separated. The bedding was softwood sawdust "Spanvall' Special White 11 from Spanvall Ltd, Jorlose, DK-4490 Jerslev.
- Diet (e.g. ad libitum): ad libitum, complete rodent diet ."Altromin 1314" from Chr. Petersen Ltd, DK-4100 Ringsted
- Water (e.g. ad libitum): tap water acidified with hydrochloric acid to pH 2.5, ad libitum
- Acclimation period: None
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21+/- 2
- Humidity (%): 55+/-15
- Air changes (per hr): 6
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations: 1, 3 and 6 hours after administration and thereafter daily; weighing on day 0, 7, 14
- Necropsy of survivors performed: yes
- Clinical signs including body weight
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Since no rats died of the treatment the oral LD50 must exceed 2000 mg ",4,4-dimethyl-3,5;8-trioxabicyclo(5.1.0)octane"/kg b. wt.. According to Regulation (EU) No. 1727/2008 (CLP) the substance does not need to be classified with respect to acute oral toxicity.
- Executive summary:
In an acute oral toxicity study according to OECD test guideline 401 (1987), groups of fasted, Wistar rats (5/sex) were given a single oral dose of 4,4-dimethyl-3,5;8-trioxabicyclo(5.1.0)octane in water at a dose of 2000 mg/kg bw and observed for 14 days.
Oral LD50 Females/Males > 2000 mg/kg bw
After single oral administration of 4,4-dimethyl-3,5;8-trioxabicyclo(5.1.0)octane at 2000 mg/kg bw to male and female rats (5/sex/group) sedation and piloerection were found as clinical signs. At autopsy, no gross pathological organ changes were observed.
4,4-dimethyl-3,5;8-trioxabicyclo(5.1.0)octane is of LOW Toxicity based on the LD50 in female and male Wistar rats, thus, 4,4-dimethyl-3,5;8-trioxabicyclo(5.1.0)octane is not classified for acute oral toxicity according to Regulation (EU) No. 1272/2008 (CLP).
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