Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, near guideline study, available as unpublished report, adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- 6 hour exposure
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 77-73-6
- Molecular formula:
- C10H12
- Details on test material:
- - Name of test material (as cited in study report): Dicyclopentadiene (DCPD)
- Physical state: clear colourless liquid at room temperature
- Analytical purity: ~97% endo- and ~1% cyclopentadiene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Industries Inc., Indianapolis, Indiana, USA
- Age at study initiation: approximately 6-7 weeks old
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: 2 per cage in stainless steel cages
- Diet: powdered chow diet ad libitum except during exposure
- Water: ad libitum except during exposure
- Acclimation period: approximately 2 weeks
ENVIRONMENTAL CONDITIONS
- Temperature: 69-74°F
- Humidity: 30-63%
- Photoperiod: 12 hrs dark /12 hrs light
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Dicyclopentadiene vapour was generated inside a heated Pyrex tube to achieve complete vaporization while keeping temperature below the point (35°C) at which fracturing to monomer occurred.
TEST ATMOSPHERE
- Chamber concentrations of DCPD and cyclopentadiene (CPD) were monitored by gas chromatography/flame ionization detection with detection limit of 0.05 ppm for both compounds. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatography/flame ionization detection
- Duration of exposure:
- 6 h
- Concentrations:
- Target concentrations were 50, 150, 300 and 600 ppm.
Actual exposure concentrations were 46, 130, 260 and 557ppm. - No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: animals were observed daily for clinical signs
- Necropsy of survivors performed: yes - Statistics:
- LC50 was calculated by the method of moving averages.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 143 ppm
- 95% CL:
- 130 - 157
- Exp. duration:
- 6 h
- Remarks on result:
- other: 774 mg/m3 air (analytical)
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 130 ppm
- 95% CL:
- 103 - 153
- Exp. duration:
- 6 h
- Remarks on result:
- other: 703 mg/m3 (analytical)
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 738.5 mg/m³ air (analytical)
- Exp. duration:
- 6 h
- Sex:
- male/female
- Dose descriptor:
- other: NOAEC for irregular breathing, stereotypic behaviour
- Effect level:
- 46 ppm
- Remarks on result:
- other: 248.74 mg/m3
- Mortality:
- There were mortalities in male and female mice exposed to 557 and 260 ppm. (The actual numbers of mice dying at the various exposure levels were not presented in the report)
- Clinical signs:
- other:
- Remarks:
- At 557 ppm, loss of righting reflex, impaired gait, stereotypic behaviour, laboured breathing, clear nasal discharge and deaths. At 260 ppm, both sexes showed stereotypic behaviour, respiratory difficulty, impaired gait, hunched posture.
- Body weight:
- No data
- Gross pathology:
- There were no gross pathological effects noted at necropsy.
Any other information on results incl. tables
Incidence of mortality following single 6-hour inhalation exposure
Target Concentration (ppm) |
Dead/dosed |
Comment |
|
|
male |
female |
|
600 |
6/6 |
6/6 |
Males: 3 dead during exposure. 1 died immediately post-exposure and 1 post-exposure. 1 died the day following exposure. Females: 1 dead during exposure. 2 died immediately post-exposure. 3 died the day following exposure. |
300 |
6/6 |
6/6 |
Males: All found dead the day after exposure. Females: 1 dead during exposure. 3 died immediately post-exposure. 2 died the day following exposure. |
150 |
2/6 |
3/6 |
Males: 2 found dead the day after exposure. Females: 1 died immediately post-exposure. 2 died the day following exposure. |
50 |
0/6 |
0/6 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Following a 6 hour whole body, inhalation exposure to dicyclopentadiene vapour, the LC50 was 143 (130-157) ppm (male) and 126 (103-153) ppm (emale). The results were not confounded by the fracturing of dicyclopentadiene into cyclopentadiene. The male/female 6 hour LC50 is equivalent to 738.5 mg/m3.
- Executive summary:
Groups of 6 male and 6 female B6C3F1 mice were exposed (whole body) to 46, 130, 260 or 557 ppm dicyclopentadiene vapour for 6 hours and then observed daily for up to 14 days. At 557 and 260 ppm, all animals died within 24 hours of exposure. At 130 ppm, 2 males were found dead on the day after exposure, 1 female died immediately post exposure and 2 died on the day following exposure. There were no deaths at 46 ppm. Clinical signs included loss of righting reflex, impaired gait, stereotypic behaviour, laboured breathing, clear nasal discharge, loss of coordination and convulsions prior to death. The LC50 was 143 ppm (male) and 126 ppm (female), equivalent to 774 and 703 mg/m3, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.