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Diss Factsheets
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EC number: 609-203-4 | CAS number: 36130-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Boiling point
Administrative data
Link to relevant study record(s)
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Jan to 16 Mar 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- other: EU Method A.1 (Melting / Freezing Temperature)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 102 (Melting point / Melting Range)
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- differential thermal analysis
- Remarks:
- Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)
- Specific details on test material used for the study:
- Purity not specified
- Key result
- Decomposition:
- yes
- Decomp. temp.:
- >= 220 - <= 420 °C
- Remarks on result:
- other: Since there were no further evidences for a boiling point or range it can be stated that the test item has no boiling point
- Conclusions:
- At higher temperatures than melting temperature at 207 °C, two exothermic phases are detected between 220 - 420 °C which indicate transformation and decomposition. Since there were no further evidences for a boiling point or range of the test item, it can be stated that Fluocortolon-21-Valerat has no boiling point.
- Executive summary:
A differential thermoanalysis method (DTA/DSC) was used to determine the melting point with test method EC A.1, 'Melting / Freezing Temperature', which corresponds with OECD Guideline 102 'Melting Point / Melting range'.
The sample was weighed in a crucible made of aluminium, cooled down in a DTA/DSC-system to 25 °C and then heated up to 450 °C (heating rate 5 K/min). In comparison with an inert sample (empty crucible) the temperature difference and the heat effect was recorded. Between approx. 190 - 215 °C an endothermic phase could be detected which indicates the melting point of Fluocortolon-21-Valerat. After the melting process two exothermic phases between approx. 220 -310 °C and approx. 325 - 420 °C were detected. These exothermic phases indicate transformation and decomposition.
Since there were no further evidences for a boiling point or range of the test item it can be stated that Fluocortolon-21 -Valerat has no boiling point.
Reference
RESULT:
- A melting point of 207 °C could be observed due to the detected endothermal effects
- After the melting of the test item two exothermal phases could be observed between 220 - 310 °C and between 325 - 420 °C
- The exothermic phases indicate transformation and decomposition
Since there were no further evidences for a boiling point or range it can be stated that the test item has no boiling point. No further investigations were made.
Validity criteria for the measurement of the boiling point:
Target condition according to guideline 92/69/EWG A.2: | Actual condition according to the study: | Validity criteria met: |
The heating rate should not exceed 10 K/min. | Heating rate was 5 K/min. | Yes |
The mean of at least two measurements which are in the range of the estimated accuracy (accuracy for this method according to the guideline is +/- 0.5 K up to 600 K) is reported as the boiling temperature. | One value was determined. | No |
The measured boiling temperatures and their mean shall be stated and the pressure(s) at which the measurements were made shall be reported in kPa. The pressure should preferably be close to normal atmospheric pressure. | The atmospheric pressure is not stated. | No. Nevertheless, although the pressure is not stated one can assume that the study was performed at atmospheric pressure as the study was performed according to guideline 92/69/EWG A.2, where specifications for the pressure are stated ("the boiling temperature is stated with regard to the ambient pressure during the measurement"). |
Description of key information
At higher temperatures than melting temperature at 207 °C, two exothermic phases are detected between 220 - 420 °C which indicate transformation and decomposition. Since there were no further evidences for a boiling point or range of the test item, it can be stated that Fluocortolon-21-Valerat has no boiling point.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.