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Diss Factsheets
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EC number: 951-407-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- dispersion stability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17th - 19th February 2021
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 318 (Dispersion Stability of Nanomaterials in Simulated Environmental Media)
- GLP compliance:
- no
- Remarks:
- It is not required for this study to be conducted to GLP
- Type of method:
- dynamic light scattering
- Specific details on test material used for the study:
- Athlos 200 Carbon Nanostructures
- Analytical monitoring:
- no
- Details on test sample/test medium:
- The sonic probe (Vibra Cell (Sonics) Ultrasonic Probe – 13 mm probe with replaceable tip) was calibrated to run at approximately 40 Watts, as per OECD Test 318
12.5 mg sample was weighed into a 250 mL beaker and Water for Injection (WFI) was added dropwise to form a paste. The mixture was sealed in the beaker with nesco-film and left at ambient for approximately 26 hours.
• The sample paste was diluted with 125 mL WFI to make an approximate concentration of 100 mg/L. Temperature of the medium 22.9°C.
• An ice bath was set up using a 2 Litre beaker and the sample beaker was held in the bath with a retort stand. Temperature of the medium 3.7°C.
• The sonic probe was inserted centrally into the sample medium at a depth of approximately 2.5 cm. The sample was sonicated for 10 minutes, Amplitude 60%, Energy 250 kJ.
• The sample beaker was carefully removed and placed against a white background to observe. A piece of filter paper was placed over the beaker to exclude dust.
OBSERVATIONS
• T = 0 mins – Initially, the bulk of the sample appeared irregularly aggregated/agglomerated, held in suspension in the WFI, with a layer of sample also held on the surface of the water. Between these two layers, a water layer with no free particulate was apparent.
• T = 10; 20; 30; 40; 50 mins – There was no perceptible change in appearance or state throughout these timepoints.
• T = 17 hours – Left at ambient overnight, there was no perceptible change. A light was placed behind and underneath the beaker, which made the water layer and sample
aggregation/agglomeration more distinct.
No free particulate was observed in the water, and the sample had a highly irregular macrostructure. - Remarks on result:
- not determinable
- Conclusions:
- Post-sonication at approximately 40 Watts, the 100 mg/L Athlos 200 Carbon Nanostructures sample solution did not form a homogeneous dispersion. Therefore, it is not possible to take a representative subsample for DLS analysis.
- Executive summary:
A study was conducted to OECD 318 guidelines to determine the dispersion stability of Athlos 200 Carbon Nanostructures. It was determined that post-sonication at approximately 40 Watts, the 100 mg/L Athlos 200 Carbon Nanostructures sample solution did not form a homogeneous dispersion. Therefore, it is not possible to take a representative subsample for DLS analysis.
Athlos 200 Carbon Nanostructures sample solution did not form a homogeneous dispersion. Therefore, it is not possible to take a representative subsample for DLS analysis.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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