Methyl formylphenylacetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Sep. 10 - Oct. 11, 2001

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Methyl formylphenylacetate

EC Number:

227-577-3

EC Name:

Methyl formylphenylacetate

Cas Number:

5894-79-1

Molecular formula:

C10H10O3

IUPAC Name:

methyl 3-oxo-2-phenylpropanoate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: NaCl 0.9%

Details on oral exposure:

the test item was administered in a single dose by gavage using an intubation cannula

Doses:

200 mg/kg
2000 mg /kg

No. of animals per sex per dose:

6 males; 3 females
3 males and 3 females exposed at 200mg/kg
3 males exposed at 2000 mg/kg

Control animals:

no

Details on study design:

A careful clinical examination was made twice a day on the day of dosing and once a day thereafter.

Cage side observations included changes in the skin and fur, eyes and mucous membranes. Also respiratory, circulatory, autonomic and central nervous systems and somatomotor activity and behavior pattern were examined. Particular attention was directed to observations of tremor, convulsions, salivation, diarrhea, lethargy, sleep and coma.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

>= 500 - < 1 000 mg/kg bw

Based on:

test mat.

Mortality:

The dosage of 200mg/kg bw caused no compound-related mortality
The dosage of 2000 mg/kg bw caused compound-related mortality in 2 of 3 male animals.

Clinical signs:

@200 mg/kg bw: No clinical signs of toxicity were observed throughout the observation period.
@2000 mg/kg bw: With showing clinical signs as reduced spontaneous activity, apathy, tremor and prone position.

Body weight:

@200 mg/kg bw: no weight loss was observed after 14-day observation
@2000 mg/kg bw: no weight loss was observed on 1 of 3 male rats after 14-day observation

Gross pathology:

No special gross pathological changes were found

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

considering the reported data of this toxicity test, it can be stated that the test item SCH 1000 / I Formylester NY has acute toxic characteristics
The LD50 was determined to be between 500 and 1000 mg/kg bw