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EC number: 230-711-3 | CAS number: 7287-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Jul 1987 to 20 Nov 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Remarks:
- ring labelled
- Analytical monitoring:
- yes
- Details on sampling:
- For each sampling period, 1 mL of solution was aseptically removed from each of the 9 flasks. Three 50 µL aliquots were removed for radioassay. The remainder of the . aliquoted solution (0.85 mL) was fortified with 100 µL of an authentic reference standard stock solution containing 0.2 mg/mL of each standard in methanol (final concentration of each standard was 0.021 mg/mL). These fortified samples were then stored in foil-covered vials at 4° C until HPLC analysis. All samples were analyzed within 7 days.
- Buffers:
- Aqueous buffered solutions were prepared at pH 5, 7 and 9 with the following compositions.
- pH 5 (Acetic acid - Sodium acetate): 146 mL of 0.1 N Acetic Acid was added to 100 mL of 0.1 N NaOH, Distilled water added to a final volume of one liter, giving a solution at pH 4.85, Adjusted to pH 5.00 with 0.1 N NaOH
- pH 7 (Potassium Dihydrogen Phosphate - Disodium Hydrogen Phosphate): 25.8 mL of 0.1 M Disodium Hydrogen Phosphate was added to 22.4 mL of 0.1 M Potassium Dihydrogen Phosphate, distilled water added to a final volume of one liter, giving a solution at pH 6.95, adjusted to pH 7.00 with 0.1 N NaOH
- pH 9 (Sodium Borate - HCl): 46 mL of 0.04 N HCI was added to 500 mL of 0.01 M Sodium Borate, distilled water added to a final volume of one liter, giving a solution at pH 8.85, adjusted to pH 9.00 with 0.1 N NaOH.
After preparation all buffered solutions were autoclaved for use in the hydrolysis study. - Details on test conditions:
- PREPARATION OF SAMPLES FOR HPLC ANALYSIS
The fortified test solutions were radioassayed prior to HPLC analysis to provide for accountability calculations upon HPLC analysis. Solutions (250µL) were directly injected onto the HPLC. - Duration:
- 30 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 1.54 g/L
- Remarks:
- For pH 5, 7 and 9
- Number of replicates:
- 3
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- no
- Key result
- pH:
- 5
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- PURITY OF [14C]-SUBSTANCE
The radiochemical purity of [14C]-substance used in this study was determined by HPLC analysis to be 98.49%.
MATERIAL BALANCE OF [14C]-SUBSTANCE THROUGHOUT STUDY PERIOD
The concentration of [14C]-substance equivalents remained very stable throughout the entire study period having a mean + S.D. of 1.71 + 0.13 ppm for all 3 pHs.
The data establish that substance is not degraded to volatile products or CO2 under the test conditions employed in this study.
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)
The HPLC method developed for use in this study provides for baseline resolution of the substance and its degradates. The recovery of radiocarbon during HPLC analysis of test solutions was also
established for each sample analyzed. The mean recovery was 99.6 ± 13.3% of the injected radiocarbon.
HYDROLYSIS OF [14C]-SUBSTANCE
Quantitative characterization of radiocarbon present in solutions incubated for 30 days at pH 5, 7, 9 revealed no hydrolysis of [14C] -substance under these conditions. With the exception of the day 7 samples, >90% of the radiocarbon in solution was identified as the substance. It is most likely that the observed degradation in the 7 day sample is due to contamination and does not, in fact, represent hydrolytic breakdown of [14C] -substance. The pH of all test solutions was measured at the end of the 30 day incubation period and found to be identical to the initial pH. The substance is therefore not subject to hydrolytic degradation at pH 5, 7 or 9 over a period of 30 days. - Validity criteria fulfilled:
- not specified
- Conclusions:
- No hydrolysis of the parent [14C]-substance was observed under these conditions.
- Executive summary:
Aqueous buffered solutions of [14C]-substance (pH 5, 7, and 9) were incubated at 25 ± 1 ° C for 30 days. [14C]-substance was found not to undergo hydrolytic degradation when tested according to FIFRA Pesticide Assessment Guidelines, Subdivision N. Chemistry: Environmental Fate S161-2 and in compliance with GLP under these conditions.
Reference
Table 1. Concentration of 14C-substance equivalents in Test Solutions Throughout the Study period
Days of incubation |
Concentration (ppm)of 14C-substance equivalents At: |
||||||||
pH 5 |
pH7 |
pH9 |
|||||||
A |
B |
C |
A |
B |
C |
A |
B |
C |
|
0 |
1.61 |
1.63 |
1.59 |
1.52 |
1.54 |
1.61 |
1.51 |
1.52 |
1.56 |
1 |
1.58 |
1.63 |
1.87 |
1.72 |
1.47 |
1.53 |
1.56 |
1.63 |
- (1) |
3 |
1.62 |
1.67 |
1.75 |
1.67 |
1.68 |
1.44 |
1.90 |
1.65 |
1.88 |
7 |
1.03 |
1.67 |
1.66 |
1.69 |
1.69 |
1.70 |
1.65 |
1.66 |
1.63 |
10 |
1.66 |
1.70 |
1.66 |
1.70 |
1.81 |
1.76 |
1.71 |
1.68 |
1.67 |
15 |
1.80 |
1.78 |
1.70 |
1.79 |
1.85 |
1.78 |
1.89 |
1.64 |
1.86 |
20 |
1.77 |
1.73 |
1.81 |
1.86 |
1.77 |
1.82 |
1.68 |
1.73 |
1.76 |
25 |
1.79 |
1.80 |
1.78 |
1.87 |
1.96 |
1.83 |
1.76 |
1.75 |
1.70 |
30 |
1.77 |
1.83 |
1.78 |
1.87 |
1.82 |
1.84 |
1.81 |
1.81 |
1.79 |
(1) Data not available - sample lost during analysis
Description of key information
All available data were assessed and the most representative study is included here as key study.
[14C]-substance was found not to undergo hydrolytic degradation under the test conditions, OECD TG 111; Kesterson 1988.
Key value for chemical safety assessment
Additional information
Aqueous buffered solutions of [14C]-substance (pH 5, 7, and 9) were incubated at 25 ± 1 ° C for 30 days. [14C]-substance was found not to undergo hydrolytic degradation when tested according to FIFRA Pesticide Assessment Guidelines, Subdivision N. Chemistry: Environmental Fate S161-2 and in compliance with GLP under these conditions.
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