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Diss Factsheets
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EC number: 233-477-0 | CAS number: 10193-36-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- See attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- other: Read Across Source
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosomal Aberration Test)
- Principles of method if other than guideline:
- METHOD FOLLOWED: cytogenetic assay using bone marrow cells
of mice
DEVIATIONS FROM GUIDELINE: not reported
GLP: no
STATISTICAL METHODS: not reported
METHOD OF CALCULATION: not reported
ANALYTICAL METHODS: not reported - GLP compliance:
- no
- Type of assay:
- mammalian bone marrow chromosome aberration test
- Species:
- mouse
- Strain:
- DBF1
- Sex:
- male
- Route of administration:
- oral: feed
- Vehicle:
- Not reported
- Details on exposure:
- BDF1 mouse, lowest dose was 740 mg/kg bw.
Highest dose is not given, but exceeded 940 mg/kg bw, the
concentration, where fatalities occurred in a range-finding
test. - Duration of treatment / exposure:
- 24h
- Frequency of treatment:
- once, on day 0. 4 mg/kg bw
colchicine was administered intraperitoneally 2 hours before
necropsy. - Dose / conc.:
- 940 mg/kg bw/day
- Remarks:
- Highest dose is not given, but exceeded 940 mg/kg bw, the concentration, where fatalities occurred in a range-finding test.
- Dose / conc.:
- 740 mg/kg bw/day
- Remarks:
- Lowest dose
- No. of animals per sex per dose:
- 4-6
- Control animals:
- yes
- Positive control(s):
- No
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not examined
- Conclusions:
- MORTALITY: not reported
CLINICAL SIGNS: not reported
NECROPSY FINDINGS: not reported
BODY WEIGHT CHANGES: not reported
FOOD AND WATER CONSUMPTION CHANGES: not reported
EFFECT ON MITOTIC INDEX OR PCE/NCE RATIO: not reported
GENOTOXIC EFFECTS: negative
NOAEL (NOEL) (C) / LOAEL (LOEL) (C): not reported
MUTANT/ABERRATION/mPCE/ POLYPLOIDY FREQUENCY: no significant
increase of chromosomal aberrations compared to negative
control even at dosage levels exceeding the M.T.D. of 940
mg/kg bw. - Executive summary:
EXAMINATIONS:
- Clinical observations: not reported
- Organs examined at necropsy: not reported
- Criteria for evaluating results: not reported
- Criteria for selection of M.T.D.: not reported.
The chromosomes were examined blind by three persons. Slides from femur bone marrow cells were prepared according to standard methods, and 100 metaphases per animal analyzed for chromosomal aberrations (including gaps, breaks, deletions and exchanges).
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test material
- Reference substance name:
- Tetrahydroxysilane
- EC Number:
- 233-477-0
- EC Name:
- Tetrahydroxysilane
- Cas Number:
- 10193-36-9
- Molecular formula:
- H4O4Si
- IUPAC Name:
- silicic acid
- Test material form:
- solid
Constituent 1
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not examined
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.