Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-864-4 | CAS number: 2921-88-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is not classified as readily biodegradable. After 28 days of incubation with activated sludge, percentage biodegradation was 22%.
The evaluation of chlorpyrifos in a natural surface water demonstrated dissipation through volatilization and hydrolysis to 3,5,6-trichloro-2-pyridinol. In the definitive test, the concentration of chlorpyrifos declined as the mass balance of the test systems declined. Mineralization to CO2was negligible (<1% AR). A subsequent experiment evaluated the volatilization of chlorpyrifos by adding a foam plug to trap any volatiles in the headspace of the sample tube. Up to 95.7% of the radioactivity was found in the foam plugs and shown to be 100% unchanged chlorpyrifos. These results demonstrate that the low mass balance observed from the later time points in the main test is due to evaporation of unchanged parent compound. Chlorpyrifos degraded in the surface water with DT50values of 46 and 21 days for the low (12 μg/L) and high (126 μg/L) concentration systems, respectively.
The transformation of chlorpyrifos was assessed in water/sediment samples from Calwich Abbey Lake and Swiss Lake, both systems were from the UK. Chlorpyrifos was applied to the water surface and samples were incubated for up to 150 days under aerobic conditions with associated overlying waters at a sediment/water ratio of 1:3 in the dark at 20 °C. Potassium hydroxide (KOH), ethylene glycol, foam plug, and Harvey Cocktail organic volatiles traps were used in flow-through aerobic test systems to collect14CO2and any volatile organic components that evolved during this study. Up to 30% of the applied radioactivity was found in the foam plug and rinses of the tubing used in the flow-through system and shown to be 100% unchanged chlorpyrifos. Chlorpyrifos also dissipated to the sediment and reached a maximum concentration of 62.4% AR at 14 days in the sediment layer. The DT50values from the water layer were 3.3 and 5.7 days for the Calwich Abbey Lake and Swiss Lake systems, respectively. The disappearance rate from the water/sediment total systems resulted in DT50values of 15 and 20 days for the Calwich Abbey Lake and Swiss Lake systems, respectively. One major metabolite was formed in the study, 3,5,6-trichloro-2-pyridinol (max. 55.9% AR, 28 days), formed by hydrolysis of the parent compound. Several minor transformation products were also formed; in all cases these transformation products represented <5% AR. Trapped14CO2accounted for less than 10% AR, with organic volatiles trapped in the ethylene glycol and Harvey cocktail not exceeding 0.1% for either system.
In studies conducted to fulfill the current OECD 307 guideline (De Vette & Schoonmade (2001) and Clark (2013a), under aerobic conditions in soil, chlorpyrifos is converted to 3,5,6-trichloro-2-pyridinol, up to a maximum of 60.2% of applied radioactivity (AR) at 14 days, by hydrolysis and microbial degradation. Further degradation to minor metabolites (<10% of applied radioactivity) including 3,5,6-trichloro-6-methoxypyridine (TMP) was observed. Mineralization to CO2generally accounted for >50% AR at study termination. Organic volatiles were not observed. Non-extractable residues (NER) accounted for up to 27% AR by study termination.
Under anaerobic soil conditions in a current GLP study (Kang, 2014a), chlorpyrifos is converted to 3,5,6-trichloro-2-pyridinol, up to a maximum of 82.7% AR, after 45 days of incubation by microbial degradation. 3,5,6-trichloro-2-pyridinol is further degraded to 3,6-dichloro-2-pyridinol (DCP) up to a maximum of 71.0% AR at study termination. Mineralization to CO2accounted for up to 5.5% AR. Organic volatiles were observed at <1% AR. NER accounted for up to 26.1% of the applied radioactivity by study termination. The DT50values of chlorpyrifos ranged 3-9 days in anaerobic soil.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.