Registration Dossier
Registration Dossier
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EC number: 701-337-2 | CAS number: -
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- 90 -days Dermal toxicity study does not have to be conducted on RDP based on available experimental information and exposure route considerations.
2 Acute Dermal toxicity studies are available on RDP. In both studies no toxicity was observed (LD50 > 2000 mg/kg) and the substance did not induce any signs of systemic toxicity on the rats. In addition, RDP was not irritant to skin or eye, and did not cause allergic skin reactions in the Skin sensitisation study. Dermal absorption of RDP is limited as indicated by series of toxicokinetic studies.
The main route of exposure for RDP is the oral route. Nevertheless, the personal precautions for users indicate explicitly the obligation for using protective rubber gloves while handling the substance.
Therefore, for the reasons stated above and since the study is costly and requires use of many animals, we believe that performing this study is not necessary and can be avoided
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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