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EC number: 640-454-2 | CAS number: 17318-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- gas saturation method
- Key result
- Test no.:
- #1
- Temp.:
- 30 °C
- Vapour pressure:
- 24.4 Pa
- Remarks on result:
- other: Saturator column flow rate at 30 mL/min
- Key result
- Test no.:
- #2
- Temp.:
- 30 °C
- Vapour pressure:
- 24.4 Pa
- Remarks on result:
- other: Saturator column flow rate at 40 mL/min
- Key result
- Test no.:
- #3
- Temp.:
- 30 °C
- Vapour pressure:
- 23.8 Pa
- Remarks on result:
- other: Saturator column flow rate at 50 mL/min
- Key result
- Test no.:
- #4
- Temp.:
- 40 °C
- Vapour pressure:
- 51.5 Pa
- Remarks on result:
- other: Saturator column flow rate at 30 mL/min
- Key result
- Test no.:
- #5
- Temp.:
- 40 °C
- Vapour pressure:
- 51.1 Pa
- Remarks on result:
- other: Saturator column flow rate at 40 mL/min
- Key result
- Test no.:
- #6
- Temp.:
- 40 °C
- Vapour pressure:
- 53 Pa
- Remarks on result:
- other: Saturator column flow rate at 50 mL/min
- Key result
- Test no.:
- #7
- Temp.:
- 50 °C
- Vapour pressure:
- 108 Pa
- Remarks on result:
- other: Saturator column flow rate at 30 mL/min
- Key result
- Test no.:
- #8
- Temp.:
- 50 °C
- Vapour pressure:
- 109 Pa
- Remarks on result:
- other: Saturator column flow rate at 40 mL/min
- Key result
- Test no.:
- #9
- Temp.:
- 50 °C
- Vapour pressure:
- 112 Pa
- Remarks on result:
- other: Saturator column flow rate at 50 mL/min
- Conclusions:
- The vapour pressure of the substance is 10 Pa at 20 °C and 16 Pa at 25 °C.
- Executive summary:
The vapour pressure of the substance was determined in accordance with OECD TG 104 under GLP.
For each of the three saturator columns, approximately 250 mg of the test item was weighed into a round bottomed flask that contained approximately 20 g of 2 mm diameter glass beads. The test item was then vigorously mixed with the glass beads on a vortex mixer. A glass wool plug was placed at the outlet of each saturator column, the coated glass beads were loaded into the saturator columns and a second glass wool plug was placed at the inlet of each saturator column.
The saturator columns were then connected to the nitrogen supply and a stream of nitrogen was passed through the saturator columns, at three different flow rates (nominal 30, 40 and 50 mL/minute) to ensure saturation control. Actual gas flow rates for each test were determined. The saturator columns were encased in a glass jacket containing water, and the test temperature maintained using a thermostatically controlled circulating waterbath. Two condensation tubes, cooled in an ethylene glycol/water mixture at approximately -20 °C, were connected in series to the outlet of each of the three saturator columns.
Three tests were performed at temperatures of 30.0, 40.0 and 50.0 °C, using gas flow times of 180, 120 and 60 minutes respectively, prior to assessing the mass of test item vaporized over this time period. After completing each test, the condensation tubes were disconnected from the saturator columns and the amount of transferred test item in each of the tubes determined analytically.
The vapor pressure of the liquid phase test item was determined to be 10 Pa at 20.0 °C (293K) and 16 Pa at 25.0 °C (298 K).
Based on the known melting temperature of the test item (22.2 °C (295.3 K), the above value represents the subcooled liquid state of the test item at 20.0 °C. Using an experimentally derived value of the latent heat of fusion, the vapor pressure of the solid phase of the test item was calculated to be 9.6 Pa at 20.0 °C (293K).
Reference
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 10 to 200 mg/L. This was satisfactory with a first order correlation coefficient of 0.9997 being obtained and the following equation for the correlation:
y = 7.4603 x 105 x + 1.6072 x 106
where:
y = peak area
x = concentration (mg/L)
To confirm specificity of the analytical method, aliquots of a standard solution and a sample solution were analyzed using a diode array detector (DAD) to record the ultraviolet spectrum of the analyte peak used for quantification. The spectra generated were consistent between the standard and sample solution.
Calculation of the final reported vapor pressure values have been performed from unrounded values, whereas individual intermediate values, such as areas, concentrations and masses presented in the tables have been rounded for the purpose of report generation. Therefore, minor discrepancies may be obtained if attempting to repeat the calculation process using reported data values presented to a reduced number of significant figures.
The comparison of the masses of test item collected in the first trap and the second for each flow rate, at each test temperature, indicated a trap collection efficiency of ≥99.94%. Therefore, two traps in series would theoretically give a condensation recovery of >99.999%.
Based on the known melting temperature of the test item (22.2 °C (295.3 K), the extrapolated experimental vapor pressure result at 20.0 °C represents the subcooled liquid state of the test item. Calculation of the vapor pressure of the solid phase of the test item at 20.0 °C (293K), using an experimentally derived value of the latent heat of fusion resulted in a value of 9.6 Pa.
Table 1: Actual test nitrogen flow rates
Test temperature |
Nitrogen flow rate (mL/minute) |
||
Saturator A |
Saturator B |
Saturator C |
|
30 °C |
31.5 |
40.5 |
53.5 |
40 °C |
31.0 |
40.0 |
51.5 |
50 °C |
31.5 |
40.7 |
51.4 |
Table 2: Analysis mean peak areas
Solution |
Mean Peak Area |
Standard at 99.5 mg/L |
7.7402 x 10^7 |
Standard at 100 mg/L |
7.7468 x 10^7 |
Matrix blank |
None detected |
30 °C test, saturator A, trap 1 |
6.9091 x 10^7 |
30 °C test, saturator A, trap 2 |
2.6179 x 10^4 |
30 °C test, saturator B, trap 1 |
8.8941 x 10^7 |
30 °C test, saturator B, trap 2 |
6.1039 x 10^4 |
30 °C test, saturator C, trap 1 |
1.1453 x 10^8 |
30 °C test, saturator C, trap 2 |
1.2965 x 10^5 |
Standard at 103 mg/L |
8.4497 x 10^7 |
Standard at 101 mg/L |
8.2770 x 10^7 |
Matrix blank |
None detected |
40 °C test, saturator A, trap 1 |
1.0081 x 10^8 |
40 °C test, saturator A, trap 2 |
6.9623 x 10^4 |
40 °C test, saturator B, trap 1 |
1.2922 x 10^8 |
40 °C test, saturator B, trap 2 |
9.1722 x 10^4 |
40 °C test, saturator C, trap 2 |
3.2040 x 10^5 |
Standard at 103 mg/L |
8.0505 x 10^7 |
Standard at 101 mg/L |
7.8971 x 10^7 |
Matrix blank |
None detected |
40 °C test, saturator C, trap 1 |
8.2222 x 10^7 |
Standard at 42.7 mg/L |
3.5269 x 10^7 |
Standard at 45.4 mg/L |
3.7638 x 10^7 |
Matrix blank |
None detected |
50 °C test, saturator A, trap 1 |
1.8204 x 10^7 |
50 °C test, saturator A, trap 2 |
8.0826 x 10^4 |
50 °C test, saturator B, trap 1 |
2.3606 x 10^7 |
50 °C test, saturator B, trap 2 |
7.0824 x 10^4 |
50 °C test, saturator C, trap 1 |
3.0616 x 10^7 |
50 °C test, saturator C, trap 2 |
9.5788 x 10^4 |
Table 3: Masses of test item condensed
Temperature (°C) |
Saturator column flow rate (mL/min) |
Concentration of sample solution (mg/L) |
Mass of test item vaporised (µg) |
Total mass of test item vaporised (µg) |
30 |
30 – trap 1 |
89.0 |
1.483 x 10^4 |
1.484 x 10^4 |
30 – trap 2 |
3.4 x 10^-2 |
1.7 |
||
40 – trap 1 |
115 |
1.910 x 10^4 |
1.910 x 10^4 |
|
40 – trap 2 |
7.9 x 10^-2 |
3.9 |
||
50 – trap 1 |
148 |
2.459 x 10^4 |
2.460 x 10^4 |
|
50 – trap 2 |
0.167 |
8.4 |
||
40 |
30 – trap 1 |
123 |
2.056 x 10^4 |
2.057 x 10^4 |
30 – trap 2 |
8.5 x 10^-2 |
4.3 |
||
40 – trap 1 |
158 |
2.636 x 10^4 |
2.636 x 10^4 |
|
40 – trap 2 |
0.112 |
5.6 |
||
50 – trap 1 |
106 |
3.518 x 10^4 |
3.520 x 10^4 |
|
50 – trap 2 |
0.392 |
19.6 |
||
50 |
30 – trap 1 |
22.0 |
2.199 x 10^4 |
2.200 x 10^4 |
30 – trap 2 |
9.8 x 10^-2 |
4.9 |
||
40 – trap 1 |
28.5 |
2.852 x 10^4 |
2.853 x 10^4 |
|
40 – trap 2 |
8.6 x 10^-2 |
4.3 |
||
50 – trap 1 |
37.0 |
3.699 x 10^4 |
3.700 x 10^4 |
|
50 – trap 2 |
0.116 |
5.8 |
Table 4: Linearity mean peak areas
Solution |
Mean Peak Area |
Matrix blank |
None detected |
Standard at 10.2 mg/L |
8.2335 x 10^6 |
Standard at 20.3 mg/L |
1.6386 x 10^7 |
Standard at 50.9 mg/L |
4.0120 x 10^7 |
Standard at 80.3 mg/L |
6.0492 x 10^7 |
Standard at 81.4 mg/L |
6.3668 x 10^7 |
Standard at 122 mg/L |
9.4231 x 10^7 |
Standard at 203 mg/L |
1.5219 x 10^8 |
Description of key information
The vapour pressure of the substance has been determined reliably in a study using a gas saturation method under GLP in accordance with OECD TG 104.
Key value for chemical safety assessment
- Vapour pressure:
- 16 Pa
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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