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EC number: 701-328-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-08-01 to 1988-08-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline test in compliance with GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Alcohols, C13-15 (odd numbered, branched and linear)
- Molecular formula:
- C13H28O and C15H32O
- IUPAC Name:
- Alcohols, C13-15 (odd numbered, branched and linear)
- Reference substance name:
- Alcohols, C13, branched glycidyl ethers
- Molecular formula:
- C16H32O2
- IUPAC Name:
- Alcohols, C13, branched glycidyl ethers
- Reference substance name:
- [(tridecyloxy)methyl]oxirane
- EC Number:
- 276-765-1
- EC Name:
- [(tridecyloxy)methyl]oxirane
- Cas Number:
- 72689-40-8
- Molecular formula:
- C16H32O2
- IUPAC Name:
- 2-[(tridecyloxy)methyl]oxirane
- Reference substance name:
- Alcohols, C15, branched glycidyl ethers
- Molecular formula:
- C18H36O2
- IUPAC Name:
- Alcohols, C15, branched glycidyl ethers
- Reference substance name:
- [(pentadecyloxy)methyl]oxirane
- EC Number:
- 302-058-5
- EC Name:
- [(pentadecyloxy)methyl]oxirane
- Cas Number:
- 94088-56-9
- Molecular formula:
- C18H36O2
- IUPAC Name:
- 2-[(pentadecyloxy)methyl]oxirane
- Reference substance name:
- secondary reaction products of Oxirane, mono{[C13-15 (odd numbered, linear and branched)-alkyloxy)methyl] derivs.
- Molecular formula:
- UVCB, not applicable
- IUPAC Name:
- secondary reaction products of Oxirane, mono{[C13-15 (odd numbered, linear and branched)-alkyloxy)methyl] derivs.
- Reference substance name:
- unknown constituents
- IUPAC Name:
- unknown constituents
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
- Specific details on test material used for the study:
- - Name of test material: Alkyl (C13-C15) - glycidylether
- Physical state: Liquid
- Analytical purity: >99%
- Lot/batch No.: DC 1295.3
- Stability under test conditions: Stable
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoer in AG. CH 4414 Fuellinsdorf / Switzerland
- Age at study initiation: male (14 weeks); females ( 15 weeks)
- Weight at study initiation: male (2.4 kg); females (2.5 - 2.6 kg)
- Housing: Individually in stainless steel cages equipped with an automatic cleaning and drinking system.
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ±3 °C
- Humidity (%): 40 - 70%
- Air changes (per hr): Air-conditioned with 10 - 15 air changes per hour.
- Photoperiod: 12 hours artificial fluorescent light; 12 hours dark.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 1 male and 2 females
- Details on study design:
- Approximately 24 hours before treatment, the dorsal fur was shaved with an electric clipper, exposing an area of approximately 100 square centimeters (10 cm ×10 cm).
On test day 1, 0.5 ml of the test article was applied to the intact skin of the shaved area. It was covered with a 3 cm × 3 cm patch of surgical gauze.
Four hours after the application, the dressing was removed and the skin was flushed with lukewarm tap water.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1.3
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Average score: 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 1
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: Average score: 0.3
- Irritant / corrosive response data:
- Local signs (mean 1 hour to 7 days) consisted of grade 0.87 erythema and grade 0.13 edema.
Slight to moderate scales at the skin of the application area were observed in all animals at day 7 after the test article treatment.
Any other information on results incl. tables
Skin irritation scores:
Time period |
Animal |
Sex |
Erythema |
Edema |
Cumulative Score |
Mean Cumulative Score |
1HR |
4 |
M |
1 |
0 |
1 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
1 |
2 |
||
24HRS |
4 |
M |
1 |
0 |
1 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
1 |
2 |
||
48HRS |
4 |
M |
1 |
0 |
1 |
1 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
0 |
1 |
||
72HRS |
4 |
M |
2 |
0 |
2 |
1.33 |
5 |
F |
1 |
0 |
1 |
||
6 |
F |
1 |
0 |
1 |
||
7 DAYS |
4 |
M |
0 |
0 |
0 |
0 |
5 |
F |
0 |
0 |
0 |
||
6 |
F |
0 |
0 |
0 |
Skin irritation: mean scores
Animal | Sex | Erythema | Edema | Cumulative Score | Mean Cumulative Score |
4 | M | 1.33 | 0 | 1.33 | 1.22 |
5 | F | 1 | 0 | 1 | |
6 | F | 1 | 0.33 | 1.33 |
Selected observations for mean scores: 24h, 48h and 72h.
Irritation
Alkyl (C13-C15)-glycidylether showed a primary irritation score of 1.22 when applied undiluted to intact rabbit skin.
Local signs (mean 1 hour to 7 days) consisted if grade 0.87 erythema and grade 0.13 edema.
Coloration
In the area of application no staining of the treated skin by pigment or coloring of the test article was observed.
Body weights
The body weight gain of all rabbits was similar.
Toxic symptoms / mortality
No acute toxic symptoms were observed in the animals during the test period, and no mortality occurred.
Necropsy
No necropsy was performed at termination of observation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study result indicated that Alkyl (C13-C15) -glycidylether was not irritating to the skin of rabbits.
- Executive summary:
This study was conducted according to OECD guideline and EU method in order to evaluate the irritation potential of Alkyl (C13-C15)–glycidylether to the skin. 1 male and 2 female rabbits were used in the study. 0.5 ml of the substance was applied to the intact skin of the shaved areas of the each rabbit for 4 hours and the untreated skin areas of the rabbit serve as the control. All rabbits were examined for signs of erythema and oedema at 24, 48 and 72 hours after patch removal.
The results showed that the substance caused slight erythema during the examination period; however, the reversibility of this reaction was observed at day 7 after the substance treatment. In addition the score for erythema and oedema formation did not meet the criteria of any category for skin corrosion/irritation under CLP.
Based on the study results, it is concluded that the substance was not irritating to the skin of the rabbits.
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