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EC number: 478-900-1 | CAS number: 6156-18-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 478-900-1
- EC Name:
- -
- Cas Number:
- 6156-18-9
- Molecular formula:
- C5 H12 S2
- IUPAC Name:
- 2,2-bis(methylthio)propane
- Details on test material:
- - Name of test material (as cited in study report): BISMETHYLTHIOPROPANE
- Synonym: BMTP
- Chemical name: 2,2-bis-methylthiopropane
- Batch number: 2KS149
- Description: colorless liquid
- Storage conditions: at room temperature and protected from light
- Purity: 97.76%
- Date of analysis: 8 November 2006
- Expiry date: November 2007.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Grimaud frères selection S.A.S., La Corbière, Roussay, France
- Age at study initiation: 2 to 4 months old
- Weight at study initiation: 3.1 ± 0.1 kg
- Housing: individually in Pajon cages (50 cm x 57 cm x 75 cm)
- Diet: free access to 110C pelleted diet (SAFE, Villemoisson, Epinay sur-Orge, France)
- Water: Drinking water filtered by a FG Millipore membrane (0.22 micron) was provided ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 ± 3
- Humidity (%): 30 to 70
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From 30 January 2007 to 10 February 2007
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Not rinced
- Observation period (in vivo):
- 1 hour, 24, 48 and 72 hours then daily up to 10 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: Kay and Calandra scale
TOOL USED TO ASSESS SCORE: hand-slit lamp and fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 9 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1 & 2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- animal: #1, 2 & 3
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- Slight or moderate chemosis (grade 1 or 2) was observed in all animals from day 1 until day 7 (two animals) or day 9 (one animal).
Slight or moderate redness of the conjunctiva (grade 1 or 2) was observed in all animals from day 1 until day 7 (two animals) or day 8 (one animal).
A clear discharge was noted in 2/3 animals on day 2; it persisted until day 4 in one of them.
An iritis (grade 1) was noted in 2/3 animals on day 1 then in all animals on day 2.
A slight corneal opacity (grade 1) was recorded in all animals on day 2; it persisted on day 3 in one of them.
Mean scores calculated for each animal over 24, 48 and 72 hours were 1.7, 2.0 and 2.0 for chemosis, 1.7, 1.3 and 2.0 for redness of the conjunctiva, 0.3, 0.3 and 0.3 for iris lesions and 0.3, 0.3 and 0.7 for corneal opacity.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Conclusions:
- BISMETHYLTHIOPROPANE was irritant when administered by ocular route to rabbits.
- Executive summary:
The potential of BISMETHYLTHIOPROPANE (BMTP) to induce ocular irritation was evaluated in rabbits according to OECD guideline 404. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. BMTP was first administered to a single male New Zealand White rabbit. Since BMTP was not severely irritant on this first animal, it was then evaluated simultaneously in two other animals. A single dose of 0.1 mL of the BMTP was instilled into the left conjunctival sac. The right eye was not treated and served as control. The eyes were not rinsed after administration of the test item. Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration and then daily until reversibility of the ocular reactions (day 10 at the latest). The mean values of the scores for chemosis, redness of the conjunctiva, iris lesions and corneal opacity were
calculated for each animal. Slight or moderate chemosis (grade 1 or 2) was observed in all animals from day 1 until day 7 (two animals) or day 9 (one animal). Slight or moderate redness of the conjunctiva (grade 1 or 2) was observed in all animals from day 1 until day 7 (two animals) or day 8 (one animal). A clear discharge was noted in 2/3 animals on day 2; it persisted until day 4 in one of them. An iritis (grade 1) was noted in 2/3 animals on day 1 then in all animals on day 2. A slight corneal opacity (grade 1) was recorded in all animals on day 2; it persisted on day 3 in one of them. Mean scores calculated for each animal over 24, 48 and 72 hours were 1.7, 2.0 and 2.0 for chemosis, 1.7, 1.3 and 2.0 for redness of the conjunctiva, 0.3, 0.3 and 0.3 for iris lesions and 0.3, 0.3 and 0.7 for corneal opacity. BISMETHYLTHIOPROPANE was irritant when administered by ocular route to rabbits.
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