5,5-dimethylhydantoin

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Data source

Reference

Reference Type:

other: QSAR model

Title:

VEGA in silico platform v.1.1.4

Year:

2017

Bibliographic source:

Daphnia Magna LC50 48h (DEMETRA) 1.0.4

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Test material information

Constituent 1

Reference substance name:

5,5-dimethylhydantoin

EC Number:

201-051-3

EC Name:

5,5-dimethylhydantoin

Cas Number:

77-71-4

Molecular formula:

C5H8N2O2

IUPAC Name:

5,5-dimethylimidazolidine-2,4-dione

Specific details on test material used for the study:

CC1(C)NC(=O)NC1=O

Test organisms

Test organisms (species):

Daphnia magna

Results and discussion

Effect concentrations

Dose descriptor:

LC50

Effect conc.:

26.14 mg/L

Remarks on result:

other: Data were predicted with VEGA DEMATRA model (v.1.0.4)

Any other information on results incl. tables

The prediction was deemed to be not reliable on the basis of the parameters listed above. The molecule does not fall into the applicability domain of the model.

Applicant's summary and conclusion

Validity criteria fulfilled:

no

Conclusions:

The Daphnia Magna LD50 was predicted to be 26.14 mg/L.