Registration Dossier
Registration Dossier
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EC number: 217-232-5 | CAS number: 1783-81-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
No experimental data are available for the assessment of skin sensitizing properties of 3-(methylthio)aniline.
The structure activity relationship of the substance was investigated in silico by using the QSAR Toolbox 4.3.1 (released 2019). No alerts for skin sensitization were identified by the Toolbox. Thus, there is no indication in silico for a skin sensitizing potential of 3-(methylthio)aniline.However, based on the structural similarity of 3-(methylthio)aniline to aniline (62 -53 -3) and the similarity of metabolism of both substances in rat liver simulated by the QSAR Toolbox, the experimental results for aniline will be taken over to 3 -(methylthio)aniline. Thus, 3 -(methylthio)aniline will be classified as skin sensitizer with Skin Sens 1B (H317) in accordance to aniline (self-classification of the registrant) as long as no experimental data are available for 3 -(methylthio)aniline itself.
A high skin permeability is predicted for 3-(methylthio)aniline in the Toolbox (Schlecker, 2019).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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