Registration Dossier
Registration Dossier
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EC number: 406-810-4 | CAS number: 40649-36-3
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
The hydrolysis of the test substance was determined according to OECD 111. Under the given conditions the DT50 is more than one year (reference 5.2.1-1).
Additional information
Hydrolysis:
The hydrolysis of the test substance was determined according to OECD TG 111. The test substance (400 mg/L) and 50 mL of the buffer solution (pH 4, 7 and 9) were put in brown iodine determination flasks. The three replicates were analysed with GC after 2.4 h and 5 days. Additionally the hydrolysis of the reference substance acetylsalicylic acid was determined the same way and analysed with HPLC. Mean values and standard deviation were calculated with a programmed pocket calculator (TI SR-51-11). The hydrolysis of the test substance was below 50% independent of the pH. The reference substance acetylsalicylic acid is totally hydrolysed after 5 days at pH 7 and 9. After 5 days at pH 4 0.1% of the start concentration was measured. After 2.4h at pH 4 72.73 % of the start concentration were measured, at pH 7 50.93% and at pH 9 45.60%. The test substance is an arylketone, theoretical no hydrolisation is possible. The test results after 2.4 h exposure in aqueous medium in a decrease in concentration of approx. 10-20%. Since the values are again higher after 5 days it can be assumed that this decline is not due to degradation, but an artifact of the method could be responsible. As the water solubility of the substance is not good, the determination of the concentration is only possible with a relatively large error. The results lead to a DT50 of the test substance in the environment of more than one year (reference 5.1.2-1).
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