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EC number: 207-993-1 | CAS number: 504-53-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The solubility of the test item was determined in non-GLP pre-tests in order to specify the solvents to be used for the AMES-, the DPRA-, the LuSens- and the h-CLAT-test.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentatriacontan-18-one
- EC Number:
- 207-993-1
- EC Name:
- Pentatriacontan-18-one
- Cas Number:
- 504-53-0
- Molecular formula:
- C35H70O
- IUPAC Name:
- pentatriacontan-18-one
- Test material form:
- solid
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Key result
- Medium:
- acetonitrile
- Remarks on result:
- other: not soluble
- Key result
- Medium:
- DMSO
- Remarks on result:
- other: The solubility of the test item was determined in non-GLP tests as indicated in the follow-ing table
- Key result
- Medium:
- acetone
- Remarks on result:
- other: The solubility of the test item was determined in non-GLP tests as indicated in the follow-ing table
- Key result
- Medium:
- other: Ethylenglykol
- Remarks on result:
- other: not soluble
- Key result
- Medium:
- other: Tetrahydrofuran
- Remarks on result:
- other: not soluble
- Test substance stable:
- not determined
Any other information on results incl. tables
Solvent |
Final Test Item Concentration |
Treatment |
Solubility |
||
Vortex |
Sonication |
soluble |
not soluble |
||
H2O demin. |
50 mg/mL |
- |
- |
- |
ok |
H2O for HPLC |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
Medium RPMI 1640 |
500 mg/mL |
ü |
30 min |
- |
ok |
Medium RPMI 1640 |
100 mg/mL |
ü |
30 min |
- |
ok |
Medium DMEM |
100 mg/mL |
ü |
30 min |
- |
ok |
Acetonitril/H2O [50%/50%] |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
Acetonitril |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
DMSO/Acetonitril [50%/50%] |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
DMSO/Acetonitril [10%/90%] |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
DMSO |
500 mg/mL |
ü |
30 min |
- |
ok |
DMSO |
100 mg/mL |
ü |
30 min |
- |
ok |
DMSO |
50 mg/mL |
- |
- |
- |
ok |
Ethylenglykol |
400 mg/mL |
ü |
- |
- |
ok |
2-Propanol |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
Aceton |
50 mg/mL |
- |
- |
- |
ok |
Tetrahydrofuran |
200 mg/mL |
- |
- |
- |
ok |
Aceton/Acetonitril [50%/50%] |
0.6 mg/mL |
2 min |
1 min |
- |
ok |
Applicant's summary and conclusion
- Conclusions:
- The test item Stearone was completely insoluble in any of the tested solvents at any of the tested concentrations
- Executive summary:
The test item Stearone was completely insoluble in any of the tested solvents at any of the tested concentrations. Therefore, none of the tests indicated in chapter2can be performed according to the respective guidelines.
Due to these results,in vitrogenotoxicity tests like Chromosomal Aberration Test (OECD 473 and EU B.10), Micronucleus Test (OECD 487 and EU B.49), Cell Gene Mutation Test using theHprtgenes (OECD 476) and Cell Gene Mutation Test using the Thymidine Kinase Gene (OECD 490) also cannot be performed according to the respective guidelines.
Thesolubility ofStearonein water according to OECD 105 resp. EU A.6 was determined in a separate study (17051108G910).
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