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EC number: 418-400-2 | CAS number: 1031-15-8 METHYL-TPP-CHLORID; MTPP-CHLORID
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan 21 - March 28, 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Feb 24, 1987
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Methyltriphenylphosphonium chloride
- EC Number:
- 418-400-2
- EC Name:
- Methyltriphenylphosphonium chloride
- Cas Number:
- 1031-15-8
- Molecular formula:
- C19H18ClP
- IUPAC Name:
- methyltriphenylphosphanium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Housing:
collective housing up to a maximum of 5 animals
per cage (Makrolon@ type III)
llumination:
artificial lighting (120 lux) from 7.00 a.m. -7.00 p.m
Temperature:
22 +/- 3°C
Relative humidity:
30-70 %
Measurement:
twice dail
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- A single oral administration of the test article was performed by gavage using a stomach tube. The test article was administered as a 2 % (group I) or a 5 % (group II) dilution in aqua ad iniectabilia in a volume of 10 ml/kg.
- Doses:
- 500 and 200 mg/kg bw
Preliminary range finding tests with doses of 2000, 1000, 500 and 200 mg/kg body weight were conducted using two female rats per dose. - No. of animals per sex per dose:
- 200 mg//kg bw: 5 males, 5 females
500 mg/kg bw: 5 males, 5 females - Control animals:
- no
- Details on study design:
- Clinical observations:
In each animal a number of clinical-toxicological signs were evaluated according to a modified Irwin-Screening procedure (Screening Methods in Pharmacology, R. A. Turner, 1965, p. 26). Any change from the normal condition was noted (increase or decrease) and the degree of severity of any clinical symptoms was assessed. The animals were examined at the fonowing post-treatment intervals: 10 min, 1 h, 2 h, 6 h, 24 h, and thereafter once daily up to day 14.
Body weights:
The body weights of an animals were recorded immediately before treatment (day 0) and surviving animals were reweighed on days 7 and 14 p.a. (termination).
Necropsy
Animals found dead were immediately necropsied. The surviving animals were sacrificed by CO2 asphyxiation after 14 days and gross pathological examinations were subsequently performed.
LD50 values were calculated by linear interpolation.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 275 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 250 mg/kg bw
- Based on:
- test mat.
- Mortality:
- at 200 mg/kg bw: 2 of 5 males, 2 of 5 females (after 14 days)
at 500 mg/kg bw: 5 of 5 males, 4 of 5 females (after 14 days) - Clinical signs:
- other: Severe dose-dependent clinical signs were observed mainly 1 and 2 h p.a. The most frequent findings were reduced activity, abnormal gait, abdominal, lateral or squatting position, abnormal body posture, decreased body tone, decreased ear, plantary and cor
- Gross pathology:
- Gross pathological examinations on animals found dead and at 14 days p. a. (terminal necropsy) revealed no test article-related findings.
The liquid filling of the gastro-intestinal tract found in animals which died within a short time after the administration was most probably caused by the administered test substance preparation. Other macroscopic changes observed were attributable to the sacrificing procedure or to minor variations which can occur spontaneously in rats of this strain and age.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the conditions of the present study, after single oral application of the test item to rats the follwing LD50 values were determined:LD50 (rat, male): ca. 250 mg/ kg bw
LD50 (rat, female): ca. 275 mg/ kg bw
LD50 (rat, male): ca. 250 mg/kg bw
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