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EC number: 417-060-2 | CAS number: 151006-61-0 1-DODECENE DIMER, HYDROGENATED; ALKANE 2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 November 1994 and 12 November 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The work described was performed in compliance with the UK Principles of Good Laboratory Practice (The United Kingdom Compliance Programme. Department of Health 1989)
Test material
- Reference substance name:
- A mixture of isomers of branched tetracosane
- EC Number:
- 417-060-2
- EC Name:
- A mixture of isomers of branched tetracosane
- Cas Number:
- 151006-61-0
- Molecular formula:
- C24 H50
- IUPAC Name:
- A mixture of isomers of branched tetracosane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Rabbits were supplied by David Percival Ltd. Moston. Sandbach. Cheshire. UK.
- Age at study initiation: Twelve to twenty weeks old
- Weight at study initiation: Animals weighed 2.43 to 2.68kg and were approximately twelve to twenty weeks old.
- Housing:Animals were individually housed in suspended metal cages.
- Diet (e.g. ad libitum): Free access to mains drinking water and food (STANRAB SQC Rabbit Diet. Special Diets Services Ltd. Witham. Essex. UK) was allowed throughout the study.
- Water (e.g. ad libitum):Free access to mains drinking water and food (STANRAB SQC Rabbit Diet. Special Diets Services Ltd. Witham. Essex. UK) was allowed throughout the study.
- Acclimation period: Seven days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Animal room maintained a temperature of 17 to 19°C.
- Humidity (%): 56 to 65%
- Air changes (per hr): Rate of air exchange was approximately 15 changes per hour
- Photoperiod (hrs dark / hrs light):Lighting controlled by a time switch to give 12 hours continuous light and 12 hours darkness.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eye remained untreated and was used for control purposes.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.1ml
- Concentration (if solution):No Data
VEHICLE
- Amount(s) applied (volume or weight with unit):Not applicable
- Concentration (if solution):Not applicable
- Lot/batch no. (if required): Not applicable
- Purity:Not applicable - Observation period (in vivo):
- Assessment of ocular damage/irritation was made approximately 1 hour and 24, 48 and 72 hours following treatment.
- Number of animals or in vitro replicates:
- 9 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done):
In group 1 the animals were treated with the test material without washing.
In group 2 three rabbits were treated in a similar manner to the unwashed group, except that 30 seconds following introduction of the test material, the treated eye was gently irrigated with 100 ml of lukewarm tap water for one minute. The contralateral eye was similarly irrigated.
- Time after start of exposure:No Data
SCORING SYSTEM:
The numerical values corresponding to each animal, tissue and observation time were recorded. The data relating to the conjunctivae were designated by the letters A (redness), B (chemosis) and C (discharge), those relating to the iris designated by the letter D and those relating to the cornea by the letters E (degree of opacity) and F (area of cornea involved). For each tissue the score was calculated as follows:
Score for conjunctivae = (A + B + C) x 2
Score for iris = D x 5
Score for cornea = (E x F) x 5
The scores for the cornea, iris and conjunctivae were totalled for each rabbit at each observation time. The group means of the total scores for each observation were then calculated.
The mean of the group mean scores at 24,48 and 72 hours was also determined. In addition, the number of rabbits showing a positive effect was recorded.
TOOL USED TO ASSESS SCORE:
Immediately before the start of the test, both eyes of the nine provisionally selected test rabbits were examined under ultra violet light after treatment with sodium fluorescin B.P. (Flourets: Smith and Nephew Pharmaceuticals Limited) for evidence of occular irritation or defect. Immediately before treatment, the rabbit eyes were again examined with the aid of light source from a standard opthalmoscope.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- other: Group 1
- Time point:
- other: 24 h
- Score:
- 0
- Reversibility:
- not specified
- Irritation parameter:
- overall irritation score
- Basis:
- other: Group 2
- Time point:
- other: 24 h
- Score:
- 0
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Group 1:Applied as Supplied, Unwashed
Individual and group mean scores for occular irritation are given in Tables 1 and 2.
No corneal or iridial effects were noted during the study.
Conjunctival redness was noted in three treated eyes one hour after treatment.
No occular effects were noted 24 hours after treatment.
Group 2: Applied as Supplied, Washed 30 seconds after application.
Individual and group mean scores for occular irritation are given in Tables 4 and 5.
No occular effects were noted during the study.
Any other information on results incl. tables
Please see attachment 1 - Tables and Attachment 2- Appendices
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material, Alkane 2, when applied as supplied and without irrigation from the eye, produced a mean 24 hour weighted Draize score of 0.0. No positive effects were noted during the study period.
The test material, Alkane 2, when applied as supplied and washed from the eye 30 seconds after treatment,produced a mean 24 hour weighted Draize score of 0.0. No positive effects were noted during the study period. The mean scores for each type of occular lesion required for EC labelling regulations are as follows:
Non-Irrigated Eye
Occular Lesion Mean Score
Corneal Opacity 0.0
Iridial lesion 0.0
Redness of conjunctivae 0.0
Chemosis of conjunctivae 0.0 - Executive summary:
A study was performed to assess the irritancy potential of the test material to the eye of the New Zealand White rabbit with or without subsequent irrigation.
The study was designed to comply with the requirements of the U.S. Environmental Protection agency (EPA) Guidelines, The OECD Guidelines for testing of chemicals No.405 " Acute eye irritation/Corrosion" (adopted 24 February 1987) and Method B5 of commission Directive 92/69/EEC ( which constitutes Annex V opf council Directive 67/548/EEC).
A single instillation of the test material to the non-irrigated eye of six rabbits produced a mean 24 hour weighted Draize score od 0.0.
Conjuntival redness was noted in three treated eyes one hour after treatment. No occular effects were noted 24 hours after treatment. No positive effects were noted.
A single instillation of the test material to the eye of another group of three rabbits, with irrigation of the eyes 30 seconds after treatment, produced a mean 24 -hour weighted Draize score 0.0.
No occular effects were noted during the study. No positive effects were noted.
The mean scores for each type of occular lesion required for EC labelling regulations are as follows:
Non Irrigated Eye
Occular Lesion Mean Score
Corneal Opacity 0.0
Iridial lesion 0.0
Redness of conjunctivae 0.0
Chemosis of conjunctivae 0.0
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