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EC number: 500-301-1 | CAS number: 111870-68-9 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 January 2018 to 18 January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- yes
- Remarks:
- no analytical confirmation os the tested concentrations due to the absence of a suitable analytical method
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Remarks:
- it was not possible to develop a suitable analytical method for this substance
- Vehicle:
- yes
- Details on test solutions:
- A primary stock concentrate of the substance with a nominal concentration of 10 g/L was prepared by weighing a nominal 0.1 g of test substance (actual weight: 0.09997 g) into a 10 mL volumetric flask and making up to volume with tetrahydrofuran (THF). The volumetric flask was manually shaken to mix and the resultant stock was observed to be clear and colourless.
Max amount of THF solvent used in all exposure solutions with the exception of the control was 100 µL/L.
Test solutions were prepared by the direct addition of the appropriate amount of concentrate to dilution water via a microliter syringe into a stirring solution in a volumetric flask. The solvent control was prepared in the same way using solvent only. The control consisted of culture medium only. - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchneriella subcapitata
- Strain: CCAP 278/4
- Source: laboratory culture:
- Age of inoculum (at test initiation): 3 days
- Method of cultivation: similar to test conditions
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Test temperature:
- 21.8-22.2 ˚C
- pH:
- 7.09-7.62
- Nominal and measured concentrations:
- nominal: 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (highest concentration selected based on low solubility)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass conical flasks of 250 mL
- Type: closed with foam bung
- Fill volume: 100 mL
- Aeration: none
- Initial cells density: nominal 0.5E04 cells/mL; measured 0.459E04 cells/mL
- Control end cells density: 46.7E04 cells/mL (medium controls); 35.9E04 cells/mL (vehicle controls)
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
- No. of vessels per vehicle control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes AAP medium
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: AAP medium according to the guideline
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no
- Photoperiod: continuous
- Light intensity: 6485 lux
EFFECT PARAMETERS MEASURED: at 24, 48 and 72 h cell density, growth rate and yield
- Determination of cell concentrations: couter counter
- Chlorophyll measurement: not included
- Other: at 72 h microscopic observations of one replicate of controls and substance concentrations
TEST CONCENTRATIONS
- Range finding study: at 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L in THF
- Results used to determine the conditions for the definitive study: mean biomass at 72 h (times E04 cells/mL): 18.70, 14.10, 12.70, 13.83, 14.30, 14.23 and 12.57 at 0, 0 (THF), 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L - Reference substance (positive control):
- no
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks:
- yield
- Duration:
- 72 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks:
- yield
- Details on results:
- The microscopic observations, made at the end of the test, showed that compared to the control the algal cells sampled from the solvent control and all test concentrations appeared normal.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The ErC50 is > 1.0 mg/L, the NOELR (growth rate) is 0.5 mg/L
- Executive summary:
In a study according to OECD 201, algae were exposed to 0, 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (vehicle THF) of the substance during 72 hours. The highest concentration was based on the limited solubility of the substance.
Effects on growth rate were seen at 1.0 mg/L, while effects on yield were observed at 0.5 mg/L. EC50 values for both growth rate and yield were > 1.0 mg/L.
Reference
Mean growth rates over the test period
Nominal concentration (mg/L) |
Mean growth rate/day (0-72 hours) |
Mean growth rate/day 95% Cl |
Percentage of solventcontrol (%) |
Culture medium control |
1.54 |
1.52-1.56 |
106 |
Solvent control |
1.45 |
1.44-1.47 |
- |
0.0625 |
1.42 |
1.39-1.45 |
98 |
0.125 |
1.44 |
1.38-1.49 |
99 |
0.25 |
1.42 |
1.39-1.46 |
98 |
0.5 |
1.41 |
1.38-1.44 |
97 |
1.0 |
1.37 * |
1.28-1.46 |
94 |
* Significant difference (p <0.05) from the solvent control.
All biological measurements are quoted to 3 significant figures and percentages to the nearest integer.
Mean yields over the test period
Nominal concentration (mg/L) |
Mean yield (0-72 hours) (104cells/ml) |
Mean yield 95% Cl (104cells/ml) |
Percentage of solventcontrol (%) |
Culture medium control |
46.2 |
43.0-49.4 |
130 |
Solvent control |
35.5 |
33.5-37.4 |
- |
0.0625 |
32.1 |
29.0-35.2 |
90 |
0.125 |
33.7 |
28.2-39.1 |
95 |
0.25 |
32.2 |
28.6-35.8 |
91 |
0.5 |
31.2 * |
28.4-34.1 |
88 |
1.0 |
27.6 * |
20.2-34.9 |
78 |
* Significant difference (p <0.05) from the solvent control.
Mean yield values are quoted to 3 significant figures.
Description of key information
In a study according to OECD 201, algae were exposed to 0, 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L (vehicle THF) of a structurally similar substance during 72 hours. The highest concentration was based on the limited solubility of the substance. Effects on growth rate were seen at 1.0 mg/L, while effects on yield were observed at 0.5 mg/L. EC50 values for both growth rate and yield were > 1.0 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 1 mg/L
- EC10 or NOEC for freshwater algae:
- 0.5 mg/L
Additional information
No studies on Castor oil, hydrogenated, propoxylated are available. In view of the structural and physico-chemical similarities between the source and the target chemical, the toxicity of Castor oil, hydrogenated, ethoxylated is considered to be representative for the toxicity of the target substance.
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