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Diss Factsheets
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EC number: 946-420-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-04-11 to 2011-04-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control, 25, 50 and 100 mg/L at 0, 24 and 48 h
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
6.25 mg test item + 1000 mL M4 medium
12.5 mg test item + 1000 mL M4 medium
25 mg test item + 1000 mL M4 medium
50 mg test item + 1000 mL M4 medium
100 mg test item + 1000 mL M4 medium
stirred for 24 h, then filtered through a filter paper
- Controls: 1000 mL M4 medium
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): slight turbidity increasing with the concentration. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Daphnia magna straus
- Source: Landesumweltamt NRW
- Food type (during holding): algae, Desmodesmus subspicatus
- Amount: not specified
- Frequency: monday to friday
ACCLIMATION
- Acclimation conditions: same as test
- Type and amount of food: Desmodesmus subspicatus
- Feeding frequency: daily, monday- friday
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 2.2-3.2 (mmol/L)
- Test temperature:
- 20.6 - 21.6°C
- pH:
- 7.85 - 8.33
- Dissolved oxygen:
- 5.6 - 6.3 mg/L
- Conductivity:
- 500-700 µS/cm
- Nominal and measured concentrations:
- nominal: 6.25, 12.5, 25, 50 and 100 mg/L (measured within 91-100% of nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 50 mL beakers
- Material, size, headspace, fill volume: Glass beakers of 50 mL volume filled with 30 mL medium
- Aeration:
- No. of organisms per vessel: 5 daphnia
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 5
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4
- Total organic carbon: 7.2 mg/L (TOC in the control was above the preset range von = 2mg/L due to problems with the carbon filter pump. However, this deviation was not considered relevant for the validity of the study as there were no immobilised daphnia in the control and TOC values of the control were substracted from TOC values of the test substance concentrations.)
- Alkalinity: 0.928 mmol/L
- Conductivity: 596 µS/cm
OTHER TEST CONDITIONS
- Adjustment of pH: yes to pH 7.4
- Photoperiod: 16 /8 light/dark cycle
- Light intensity: 700 ± 50 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation at 0, 24 and 48 h
VEHICLE CONTROL PERFORMED: no
RANGE-FINDING STUDY
- Test concentrations: yes, non-GLP pre-test, concentrations not specified
- Results used to determine the conditions for the definitive study: The test item was identified to be poorly soluble in M4 medium, therefore the nominal concentrations 6.25, 12.5, 25, 50 and 100 mg/L were used in the test. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 32.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: 0%
- Other adverse effects control: none - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48 h EC50 of polyglycerin caprylate/caprinate to Daphnia magna was 32.1 mg a.i./L (analytically verified nominal concentration).
- Executive summary:
The 48 h acute toxicity of polyglycerin caprylate/caprinate to Daphnia magna (Straus) was studied under static conditions according to OECD Guideline 202 (2004) and EU method C.2 (2008). Daphnids were exposed to control and test chemical at nominal concentration of 6.25, 12.5, 25, 50 and 100 mg a.i./L for 48 h (analytical verification by TOC measurement). Immobilization and sublethal effects were observed daily and at test termination. The 48 hour EC50 was 32.1 mg a.i./L. The NOEC based on immobilization was 25.0 mg a.i./L.
Results Synopsis
Test Organism Age:< 24 h
Test Type: Static
48 h EC50: 32.1 mg a.i./L 95% C.I.: n.d.
Endpoint Effected: Immobilisation
Reference
Table 1: Nominal and measured concentrations for [48 h] TOC calculation
|
Measured concentration (Unit) results |
|||
Nominal concentr. |
control (M4 medium) |
25 |
50 |
100 |
TOC (mg/L) |
7.6 |
11.1 |
23.8 |
42.9 |
% of nominal (ref. to TOC at 0h) |
105.55 |
94.87 |
91.89 |
90.88 |
Description of key information
48 h EC50: 32.1 mg a.i./L (OECD TG 202; RL1; GLP: static, Daphnia magna)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 32.1 mg/L
Additional information
The 48 h acute toxicity of polyglycerin caprylate/caprinate to Daphnia magna (Straus) was studied under static conditions according to OECD Guideline 202 (2004). Daphnids were exposed to control and test chemical at nominal concentration of 6.25, 12.5, 25, 50 and 100 mg a.i./L for 48 h (analytical verification by TOC measurement). Immobilization and sublethal effects were observed daily and at test termination. The 48 hour EC50 was 32.1 mg a.i./L. The NOEC based on immobilization was 25.0 mg a.i./L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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