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Diss Factsheets
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EC number: 219-698-5 | CAS number: 2499-95-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Range Finding Toxicity Data: List VII
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Strigel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal 30:470
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Non-fasted animals were treated with a single dose by gastric intubation and observed during 14 days. This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948).
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Hexyl acrylate
- EC Number:
- 219-698-5
- EC Name:
- Hexyl acrylate
- Cas Number:
- 2499-95-8
- Molecular formula:
- C9H16O2
- IUPAC Name:
- hexyl prop-2-enoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
-Source: Mellon Institute
-Age at study initiation: 4-5 weeks
-Weight at study initiation: 90-120 g
-Diet: Rockland Rodent diet
Water: ad-libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Details on oral exposure: undiluted substance
- Doses:
- Logarithmic differing by a factor of 2 (no further detail)
- No. of animals per sex per dose:
- 5 Males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed daily for mortality; frequency of weighing not specified.
- Necropsy of survivors performed: no
- Statistics:
- LD 50 calculated by method of Thompson (Bacteri Rev 11: 115 June 1947 Use of moving averages and interpolation to estimate median effective dose) and tables of Weil (Biometrics 8: 249 Sept 1952: Tables for convenient calculation median-effective dose (LD50 or ED50) and instructions in their use). The LD50 is given with ± 1.96 standard deviations.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 22 932 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 18.9 - <= 35.8
- Remarks on result:
- other: original data: 26.0 ml/kg LD50 (mg/kg)= LD50 (ml/kg) x density x 1000 = 26.0 x 0.882 x 1000 = 22932.0 mg/kg
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for n-hexyl acrylate following oral intubation was established at ca. 22392 mg/kg bw (26.0 mL/kg) for males. This finding does not warrant classification of n-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
- Executive summary:
In the key study (Smyth 1969), male rats were treated orally with single doses of n-hexyl acrylate and observed during 14 days. This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948). The LD50 for n-hexyl acrylate following oral intubation was established at ca. 22392 mg/kg bw (26.0 mL/kg) for males. This finding does not warrant classification of n-hexyl acrylate as an acute oral toxicant under the Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).
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