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Diss Factsheets
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EC number: 944-090-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
The in vitro genotoxicity of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is expected to be driven by the properties of its individual constituents. Therefore the in vitro genotoxicity of the substance was assessed based on information on its constituents regarding their capacity to induce gene mutation in bacteria and mammalian cells and structural chromosomal aberration in mammalian cells.
Based on a combination of experimental data and valid QSAR predictions, it was concluded that the constituents of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) will not induce gene mutation in bacteria and mammalian cells and structural chromosomal aberration in mammalian cells.
It is therefore concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce gene mutation in bacteria and mammalian cells and structural chromosomal aberration in mammalian cells.
It is not considered relevant to perform in vitro or in vivo genotoxicity in accordance with Annexes VII and VIII of REACH.
Link to relevant study records
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Adequacy of study:
- weight of evidence
- Study period:
- June 06, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- GLP compliance:
- no
- Type of assay:
- other: In vitro mammalian cell micronucleus test, other (not specified)
- Key result
- Remarks on result:
- other: The substance is not expected to induce structural chromosomal aberration in mammalian cells based on the properties of its constituents.
- Conclusions:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance. Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce structural chromosomal aberration in mammalian cells. It is not considered necessary to carry out further testing.
- Executive summary:
The potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce structural chromosomal aberration in mammalian cells is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, morpholine, and water – to induce structural chromosomal aberration in mammalian cells.
Available data and QSAR predictions on these constituents indicate that they will not induce structural chromosomal aberration in mammalian cells
Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce structural chromosomal aberration in mammalian cells. It is not considered necessary to carry out further testing.
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Adequacy of study:
- weight of evidence
- Study period:
- June 06, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- GLP compliance:
- no
- Type of assay:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Key result
- Remarks on result:
- other: The substance is not expected to induce gene mutation in bacteria based on the properties of its constituents.
- Conclusions:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance. Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce gene mutation in bacteria. It is not considered necessary to carry out further testing.
- Executive summary:
The potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce gene mutation in bacteria is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, morpholine, and water – to induce gene mutation in bacteria.
Available data and QSAR predictions on these constituents indicate that they will not induce gene mutation in bacteria.
Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce gene mutation in bacteria. It is not considered necessary to carry out further testing.
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Adequacy of study:
- weight of evidence
- Study period:
- June 06, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- GLP compliance:
- no
- Type of assay:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Key result
- Remarks on result:
- other: The substance is not expected to induce gene mutation in mammalian cells based on the properties of its constituents.
- Conclusions:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance. Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce gene mutation in mammalian cells. It is not considered necessary to carry out further testing.
- Executive summary:
The potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce gene mutation in mammalian cells is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, morpholine, and water – to induce gene mutation in mammalian cells.
Available data and QSAR predictions on these constituents indicate that they will not induce gene mutation in mammalian cells.
Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce gene mutation in mammalian cells. It is not considered necessary to carry out further testing.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The capacity of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce gene mutation in bacteria and mammalian cells and structural chromosomal aberration in mammalian cells was assessed using a combination of available experimental data and valid QSAR predictions on the individual constituents of the substance. As none of these constituents are genotoxic it was concluded that the substance was not genotoxic.
In accordance with Annexes VII and VIII of REACH it was not required to consider in vivo genotoxicity testing on Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) as no positive result was obtained.
As a conclusion Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) does not meet the criteria for classification as mutagenic in accordance with Regulation (EC) N° 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.