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Diss Factsheets
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EC number: 239-620-3 | CAS number: 15571-48-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation
- Author:
- Andreas Natsch, Cindy A. Ryan, Leslie Foertsch, Roger Emter,
Joanna Jaworska, Frank Gerberick and Petra Kern - Year:
- 2 013
- Bibliographic source:
- J. Appl. Toxicol. 2013; 33: 1337–1352
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 442E (In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome pathway for Skin Sensitisation)
- GLP compliance:
- not specified
- Type of study:
- other: direct peptide binding assay, activation of keratinocytes, and activation of dendritic cells
Test material
- Reference substance name:
- Propan-2-ol
- EC Number:
- 200-661-7
- EC Name:
- Propan-2-ol
- Cas Number:
- 67-63-0
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Propanol-(2) (2-propanol, isopropyl alcohol )
- Substance type: organic
- Physical state: liquid
Constituent 1
In vitro test system
- Details on the study design:
- This study was carried out at the time that the current OECD guideline in vitro tests for sensitization were in ECVAM prevalidation. It compares the results of a standard 3 tests in vitro testing battery against quality LLNA in vivo data, which had all been obtained according
to the OECD 429 protocol and had shown a clear dose–response curve or negative result. Considering chemical availability, compatibility with assay conditions (e.g. suitable solubility in testing medium), no interference with read out in assay (e.g. no co-elution in HPLC for the DPRA), and a good coverage of non-sensitizer and sensitizers of different sensitization potencies, chemicals were chosen and tested. A complete set of in vivo and alternative in vitro data was compiled for 145 different chemicals, with only three data gaps for the U937-CD86 test (OECD Guideline 442E: In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome pathway for Skin Sensitisation).
Results and discussion
In vitro / in chemico
Resultsopen allclose all
- Run / experiment:
- other: DPRA
- Parameter:
- other: Cysteine [% pept. remain.]
- Value:
- 100
- Run / experiment:
- other: DPRA
- Parameter:
- other: Lysine [% pept. remain.]
- Value:
- 99.5
- Remarks on result:
- no indication of skin sensitisation
- Run / experiment:
- other: KeratinoSens assay
- Parameter:
- other: EC1.5, EC3, and IC50 (mM)
- Value:
- 2
- Remarks on result:
- no indication of skin sensitisation
- Run / experiment:
- other: U937-CD86 test.
- Parameter:
- other: EC150 (mM)
- Value:
- 7
- Remarks on result:
- no indication of skin sensitisation
- Other effects / acceptance of results:
- In this study, 145 different chemicals were tested in vitro and compared against good quality in vivo LLNA data. In vitro test results for isopropanol are in accordance with the in vivo LLNA. The study documented a good sensitivity, specificity and accuracy for the in vitro approach when validated against the LLNA (82, 77, and 81%, n=145).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Isopropanol was reported negative in both a guideline local lymph node assay and a, guideline comparable, in vitro battery of 3 tests, which comprised a DPRA, KeratinoSens assay and U937-CD86 assay. The test battery was carried out on 145 chemicals and the study documented a good sensitivity, specificity and accuracy for this approach when validated against good quality in vivo LLNA data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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