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EC number: 244-239-0 | CAS number: 21142-29-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The key study for acute oral toxicity reports an LD50 of >5000 mg/kg bw in rat (WIL, 1995). The study was conducted according to current guideline and in compliance with GLP.
The key study for acute dermal toxicity reports an LD50 of >2000 mg/kg bw in rat (WIL, 1995). The study was conducted according to current guideline and in compliance with GLP.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 October 1995-08 May 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA FIFRA/TSCA and Japanese MAFF guidelines
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Crl:CDBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, NY
- Age at study initiation: young adult
- Weight at study initiation: 217 - 278 g
- Fasting period before study:
- Housing: Individual housing, suspended wire mesh cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum of 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71.3-72.1
- Humidity (%): 42.3-62.5
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5.05 ml/kg
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5M/5F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the rats were observed 1, 3 and 4 hours post-dose on day 0 and twice daily thereafter. Body weights were obtained and recorded on study days -1, 0, 7, 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Major organ systems of the cranial, thoracic and abdominal cavities were examined for all animals. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: All clinical findings were within three days of dosing. Wet yellow urogenital staining was observed for nine animals. Mucoid faeces and soft stool were each noted for single animals. One rat had dried red material on the forelimbs. There were no other cli
- Gross pathology:
- Enlarged cervical lymph nodes were observed for a single animal at the terminal necropsy. There were no other necropsy findings.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An LD50 of >5000 mg/kg bw is reported for the registered substance in a study that was conducted according to current guideline and in compliance with GLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The study was conducted according to current guideline and in compliance with GLP.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May - July 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA FIFRA/TSCA and Japanese MAFF guidelines
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Crl:CDBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, NY
- Age at study initiation: young adult
- Weight at study initiation: 239 - 269 g
- Housing: Individual housing, suspended wire mesh cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum of 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71.3-72.1
- Humidity (%): 42.3-62.5
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flank
- % coverage: 20-25
type of wrap: gauze bandage
: - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the rats were observed 1, 3 and 4 hours post-dose on day 0 and twice daily thereafter. Body weights were obtained and recorded on study days 0, 7 and 14. The application sites were examined for erythema, edema and other dermal findings ca. 30-60 minutes after bandage removal and daily thereafter for thirteen days. The rats were clipped to facilitate dermal observations on study days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: Major organ systems of the cranial, thoracic and abdominal cavities were examined for all animals. - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Clinical findings were limited to wet yellow urogenital staining for five rats and dried red material around the eye(s) and/or nose for four rats. These findings are typically noted in association with the bandage/collar application procedures and were no
- Gross pathology:
- Dark, red lungs were present for one female. There were no gross necropsy findings for all examined tissues.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An LD50 of >2000 mg/kg bw is reported in a study which was conducted according to current guideline and in compliance with GLP.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The study was conducted according to current guideline and in compliance with GLP.
Additional information
The key study for acute oral toxicity reports an LD50 of >5000 mg/kg bw, in a study which was conducted according to current guideline and in compliance with GLP (WIL, 1995). There were no deaths during the study. All clinical findings were within three days of dosing. Wet yellow urogenital staining was observed for nine animals. Mucoid faeces and soft stool were each noted for a single animal. One rat had dried red material on the forelimbs. There were no other dermal findings. All animals appeared normal by day 4 or earlier and throughout the remainder of the study. There were no remarkable changes or differences in body weights. Enlarged cervical lymph nodes were observed for a single animal at the terminal necropsy. There were no other necropsy findings.
Acute oral toxicity studies with the analogous substances, 3-(trimethoxysilyl)propyl methacrylate (CAS 2530 -85 -0) and 3-(trimethoxysilyl)methyl methacrylate (CAS 54586-78-6) have been included in the data set for completeness (Dow Corning Corporation, 2001; Bioservice, 2003; WIL, 2001) to support read-across of skin sensitisation data.
The key study for acute dermal toxicity reports an LD50 of >2000 mg/kg bw, in a study which was conducted according to current guideline and in compliance with GLP (WIL, 1995). There were no deaths during the study. Clinical findings were limited to wet yellow urogenital staining for five rats and dried red material around the eye(s) and/or nose for four rats. These findings are typically noted in association with the bandage/collar application procedures and were not a result of test material application. There were no other clinical findings. All animals appeared normal by day 2 or earlier and throughout the study. The test material induced very slight erythema on seven animals. There was no edema. Desquamation was present on two animals on day 7. There were no other dermal findings. All dermal irritation completely subsided by day 8 or earlier. There were no remarkable changes or differences in body weights. Dark, red lungs were present for one female. There were no gross necropsy findings for all examined tissues.
Justification for classification or non-classification
Based on the available data, no classification is required for acute toxicity in accordance with Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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