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EC number: 230-898-1 | CAS number: 7360-53-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June - July 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline- and GLP-compliant study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium triformate
- EC Number:
- 230-898-1
- EC Name:
- Aluminium triformate
- Cas Number:
- 7360-53-4
- Molecular formula:
- CH2O2.1/3Al
- IUPAC Name:
- aluminium triformate
- Details on test material:
- Test article: Altriform CFD
Chemical name: Aluminiumtriformiat
Article No.: 335204
Batch No.: 46799/01
Activity: approx. 97%
Description: White powder
Stability: 12 months
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: DIMED Schönwalde GmbH, D-16352 Schönwalde
- Weight at study initiation: 140 - 160 g
- Fasting period before study: ca. 18 hours
- Housing: transparent polycarbonate cages (macrolone type III)
- Diet (e.g. ad libitum): Altromin 1314
- Water (e.g. ad libitum): domestic quality drinking water acidified with HCl to pH 2.5
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 °C +/- 3 °C
- Humidity (%): 55 % +/- 15 %
- Air changes (per hr): 10/hour
- Photoperiod (hrs dark / hrs light): 12hrs/12hrs
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
Dose: 2000 mg/kg body weight
Dose volume: 10 mL/kg body weight
- Rationale for the selection of the starting dose:
The study was initiated with a sighting study: One female rat was dosed with 2000 mg/kg b.w. Only slight signs of toxicity and no mortality were observed. - Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1, 3 and 6 hours after the administration and daily thereafter for 14 days
- Frequency of weighing: Body weight was recorded on days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
- Preliminary study:
- Sighting study with one female, dosed with 2000 mg/kg: The animal survived the treatment, showed only slight signs of toxicosis (piloerection 1 and 3 h after administration) and had a normal body weight gain during the study period. No pathological abnormalities were revealed at the post mortem inspection.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animal died on account of the treatment.
- Clinical signs:
- other: All animals showed piloerection 1 and 3 hours after the application of the test article. After 6 hours until the end of the observation period no abnormalities were revealed.
- Gross pathology:
- The gross necropsy of the animals revealed no pathological abnormalities.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the experimental conditions the discriminating dose level of Aluminiumtriformiat, Batch No. 46799/01, in rats was found to be 2000 mg/kg body weight (LD50, oral, rat > 2000 mg/kg bw).
- Executive summary:
The acute oral toxicity in rats was determined according to the method recommended in the OECD Guideline No. 420, "Acute Oral Toxicity - Fixed Dose Method", July 1992 and the corresponding EEC Guideline B.1 bis "Acute Toxicity (Oral)", January 1997.
The study was initiated with a sighting study, in which one female rat was given Aluminiumtriformiat in a 2000 mg/kg body weight dose. Slight signs of toxicity were observed in this rat.
Based on the results from the sighting study the main study was carried out with one group consisting of 5 male and 5 female animals given a dose of 2000 mg/kg body weight.
All animals in the main study survived the treatment and showed only slight signs of toxicosis.
Under the experimental conditions the discriminating dose level of Aluminiumtriformiat, Batch No. 46799/01, in rats was found to be 2000 mg/kg body weight and the LD50 (oral, rat) was > 2000 mg/kg body weight..
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