Registration Dossier
Registration Dossier
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EC number: 244-526-0 | CAS number: 21679-31-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jusqu'à 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VIII.
- Author:
- Carpenter C, Weil CS, Smyth HF
- Year:
- 1 974
- Bibliographic source:
- Toxicology and Applied Pharmacology 28: 313-319
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chromium(III) 4-oxopent-2-ene-2-olate
- EC Number:
- 244-526-0
- EC Name:
- Chromium(III) 4-oxopent-2-ene-2-olate
- Cas Number:
- 21679-31-2
- Molecular formula:
- C15H21CrO6
- IUPAC Name:
- chromium(III) 4-oxopent-2-ene-2-olate
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Aucun
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Aucun
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Non disponible
- Doses:
- Non disponible
- No. of animals per sex per dose:
- Non disponible
- Control animals:
- not specified
- Details on study design:
- Non disponible
- Statistics:
- Non disponible
Results and discussion
- Preliminary study:
- Pas applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 360 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Non disponible
- Clinical signs:
- Non communiqué
- Body weight:
- Non communiqué
- Gross pathology:
- Non communiqué
- Other findings:
- Aucun
Applicant's summary and conclusion
- Interpretation of results:
- other: Substance non classifiée
- Conclusions:
- La substance à enregistrer (Acétylacétonate de chrome) n'apparait pas comme nocive (DL50 comprise supérieure à 2000 mg/kg de poids corporel) pour les rats dans les conditions de test utilisées.
- Executive summary:
L'acétylacétonate de chrome a été administré à des groupes de rats par voie orale. Une DL50 de 3360 mg/kg de poids corporel a été établie pour l'acétylacétonate de chrome.
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