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Diss Factsheets
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EC number: 231-185-8 | CAS number: 7443-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: expert statement
Reference
Description of key information
There are no studies available in which the toxicokinetic properties of the substance were investigated.
The test item, an organic substance, which is solid (white powder) at room temperature is weakly hydrolytically unstable and hydrolyses within several days, depending on the pH value (see IUCLID chapter 5.1.2). The substance is slightly water solube (91 mg/L; see IUCLID chapter 4.8). The octanol water partition coefficient (Log Pow) for the substance was determined to be 2.4 (see IUCLID chapter 4.7).
Absorption
With reference to the slight solubility in water, its molecular weight below 500 and a Log Pow of 2.4 absorption of the substance has principally to be considered (please refer to ECHA Guidance on information requirements and chemical assessment, R.7c, Table R.7.12-1, (V3.0; 2017, p. 181)). Also the observation that the substance is not ionisable strengthens the conclusions that the substance can principally be absorbed (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 167). This assumption is especially strengthened by the results of a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (OECD 422): NOAEL 300 mg/kg bw/d (adverse changes only observed in highest dose group). These data indicate that some amounts of the substance are bioavailable.
Distribution
Taking into account the slight water solubility of the substance as well as its Log Pow value it can be assumed that it will migrate into cells and concentration in adipose tissues or other systemic compartments cannot be ruled out (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, pp. 176-177).
Metabolism
There is no information on the metabolism of the substance. But hydrolysis of the ester and ether groups as well as ring hydroxylation seems to be possible mechanisms.
Excretion
With reference to the slight solubility of the substance as well as its low molecular weight urinary excretion might be considered as the most favorable excretion route. (please refer to ECHA Guidance on information requirements and chemical assessment, Chapter R.7c, p. 178).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
none
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.