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Diss Factsheets
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EC number: 234-634-6 | CAS number: 12018-10-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A guideline-compliant and GLP-compliant acute study is available for the material 'Chromoxyd Dyko' (containig 96% chromium oxide), which shows low acute oral toxicity; similar findings are seen in two additional proprietary studies performed with chromium oxide and chromium hydroxide. No information is available on acute dermal toxicity. The results of a modern, proprietary GLP and guideline-compliant study (Gaunt, 2009) reports an LC50 value of >5.41 mg/L.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 410 mg/m³ air
Additional information
Acute oral toxicity
The acute oral LD50 of 'Chromoxyd Dyko' (96% chromium oxide, 4% titanium dioxide) in the rat was found to be >5000 mg/kg bw in a guideline- and GLP-compliant study (Bomhard, 1988). Titanium dioxide is known to be toxicologically inert and can therefore be disregarded for the purposes of this study.
The acute oral LD50 of 'Chromoxid Extra' (chromium hydroxide) was also found to be >5000 mg/kg bw (Loeser, 1981). The results of this study, performed with a similar Cr (III) salt of low water solubility can be extrapolated to chromium oxide.
In a further study, the acute oral LD50 of 'Chromoxid Grun GN' (chromium oxide) was found to be >15000 mg/kg bw (Loeser, 1972). This further confirms the low acute toxicity of the substance.
Acute dermal toxicity
No information is available on acute dermal toxicity, however based on the very low acute oral toxicity and very low dermal penetration, toxicity by this route can confidently be predicted to be very low. No testing is therefore proposed, based on scientific and animal welfare considerations.
Acute inhalation toxicity
The results of a modern, proprietary GLP and guideline-compliant study (Gaunt, 2009) reports an LC50 value of >5.41 mg/L.
Justification for classification or non-classification
Chromium oxide is not listed on Annex I of Directive 67/548/EEC.
It is not proposed to classify chromium oxide for acute oral or inhalation toxicity (based on experimental results) or for acute dermal toxicity (based on scientific consideration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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