Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-127-6 | CAS number: 78-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification below and the overall justification for grouping of substances attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 126 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 126 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-06-30 to 2008-07-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: The test article concentration was measured in each test chamber at test initiation (before the addition of the fish) and at test termination.
- Sampling method: Water samples (10 mL) were collected from mid-depth of the test chambers using a glass pipette. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The nominal test concentration was 120 mg/L. Appropriate aliquots (3.6 g) of the test article were added directly to 30-L of aerated dilution water in the test chambers. The mixtures were stirred using a glass pipette for approximately 1 minute. The negative control was dilution water only. All test solutions appeared clear and colorless. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Thomas Fish Company, Anderson, California on June 27, 2008. The identity of the species was verified by the supplier.
- Length at study initiation (length definition, mean, range): 49 mm (46-52 mm)
- Holding conditions: The fish were held at a temperature of 11.6 to 11.7ºC.
- Type and amount of food: During holding, rainbow trout were fed finfish starter #2 obtained from Zeigler Brothers, Gardners, PA. The trout chow is analyzed annually for selected contaminants. No contaminants had been shown to be present in the trout chow at concentrations that might affect the outcome of this study. Feeding was discontinued at least 48 hours prior to test initiation and the fish were not fed during the test.
- Health during acclimation (any mortality observed): no mortality - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 111 mg/L as CaCO3
- Test temperature:
- 12+/-1°C
- pH:
- 7.6-8.4
- Dissolved oxygen:
- ≥8.7 mg/L
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0 (Control) and 120 mg/L
Measured concentrations at test initiation: 120-126 mg/L
Measured concentrations at test termination: 128-131 mg/L
Mean measured test concentration: 126 mg/L (105% of nominal) - Details on test conditions:
- TEST SYSTEM
- Test vessel: Test chambers were 38-L glass aquaria containing approximately 30 L of test solution. Test chambers were impartially placed in a temperature-controlled environmental chamber set to maintain a temperature of 12+/-1ºC. Each test chamber was loosely covered with a piece of plexiglass. Test chambers were labeled with the study number, test article concentration and replicate.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- Biomass loading rate: 0.28 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The dilution water was municipal water obtained from Bay City, Michigan. The water was dechlorinated using a carbon filter and aerated prior to use.
- Culture medium different from test medium: No
- Intervals of water quality measurement: The laboratory water is monitored weekly for hardness, alkalinity, conductivity, total residual chlorine and pH. . The water is monitored once a year for selected inorganics, total suspended solids (TSS), total organic carbon (TOC) and selected organic compounds. No contaminants have been shown to be present in the water at concentrations that might affect the outcome of this study.
OTHER TEST CONDITIONS
- Light intensity: Lighting used to illuminate the test vessels was provided by cool white fluorescent bulbs with a photoperiod of 16 hours light and 8 hours dark. Light intensity at test initiation was 34 foot-candles.
EFFECT PARAMETERS MEASURED: Mortality after 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test
- Results used to determine the conditions for the definitive study: - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 126 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 126 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Mortality of control: 0%
- Reported statistics and error estimates:
- The 24, 48, 72 and 96-hour LC50 values were estimated by visual inspection of the mortality data. Confidence limits could not be calculated because only one concentration was tested.
- Sublethal observations / clinical signs:
No mortality or other effects were observed in the control or treated test media.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-hour LC50 of >126 mg/L and a NOEC of ≥126 mg/L have been determined for the effects of the test substance on mortality of Oncorhynchus mykiss.
Referenceopen allclose all
Description of key information
LC50 (96 h) > 126 mg/L (mean measured concentration, OECD 203)
Key value for chemical safety assessment
Additional information
There are no data available on short-term toxicity to fish for Diethoxy(dimethyl)silane (CAS 78-62-6). In accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances and read-across” and in accordance with the read across assessment framework (RAAF, ECHA 2017) a read-across from the analogue substance dimethylsilanediol (CAS 1066-42-8) has been applied to support the environmental hazard assessment of diethoxy(dimethyl)silane (CAS 78-62-6). Details on the read across justification can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13. The study with the analogue substance dimethylsilanediol (CAS 1066-42-8) was performed according to OECD 203 (GLP). Oncorhynchus mykiss was exposed to the substance in a limit test to a test item concentration of 120 mg/L (nominal) and a control under static conditions. The test concentration remained stable for the duration of the study resulting in a mean measured test concentration of 126 mg/L (105% of nominal). No mortality was recorded after 96 h resulting in a LC50 (96 h) > 126 mg/L
Based on these results of the analogue substance, Diethoxy(dimethyl)silane (CAS 78-62-6) is not assumed to cause harmful effects towards fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.