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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 946-756-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test: Oral administration of the test item to healthy human volunteers
- Parameters analysed / observed: Quantification of total lipids anf free fatty acids, quantification of CLA and its metabolites - GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 27
- Sex: male/female
- Age: > 30, < 40 years - Ethical approval:
- confirmed, but no further information available
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- measured
- Details on exposure:
- A capsule which contained 1 g of 80 % CLA (63 % c9t11, 13 % t10,c12, 3 % cll,t13), 14 % oleic acid, 3 % linoleic acid and 5 % palmitic acid) was given daily for two months.
Group 1 served as control with no CLA supplement.
• Group 2 was assigned to a dietary intake of 0.8 g/d CLA
• Group 3 was assigned to a dietary intake of 1.6 g/d CLA
• Group 4 was assigned to a dietary intake of 3.2 g/d CLA - Examinations:
- - Other:
Quantification of total lipids and free fatty acids and of CLA and its metabolites in blood samples.
Results and discussion
Any other information on results incl. tables
The plasma concentration of c9,t11 CLA increased linearly 3-, 6- and 11-fold, with respect to unsupplemented controls, following dietary supplementation with 0.8, 1.6 or 3.2 g/d of CLA intake, respectively. The metabolites of c9,t11 CLA after delta 6 desaturation (CD 18:3) increased 1.5-, 2- and 4- fold with respect to unsupplemented controls, while CD 20:3 reached a plateau at 4-fold increase after 1.6 g/d CLA intake. The peroxisomal beta oxidation product, CD 16:2, increased of 1.5-, 2- and -3 fold in plasma. The ratio be tween the plasma value of CD 16:2 and CLA which indicates the peroxisomal beta oxidation ratio, decreased linearly up to 1.6 g/d CLA intake, and stabilised at this level of CLA intake. CLA supplementation between 0.8 and 3.2 g/d did not cause any significant changes in plasma cholesterol levels. After two months wash out period, plasma levels of CLA returned to basal levels, for all levels of dietary CLA supplementation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.