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Diss Factsheets
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EC number: 215-264-4 | CAS number: 1317-34-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
No data is available for the target substance dimanganese trioxide. Thus, to assess the potential to induce skin sensitisation of the target substance, available data from manganese oxide (source substance) was used in read-across approach. The source substance was tested negative in an in vivo Local Lymph Node assay conducted in accordance with OECD test guideline 429. Based on this result, the target substance dimanganese trioxide is not considered to be a skin sensitizer.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read-across please refer to the read-across statement in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Positive control results:
- The Stimulation Index for Phenylacetaldehyde (90%) was considered to be a positive sensitiser under the conditions of the test (see Table 1 in box 'Any other information on results incl. tables').
- Key result
- Parameter:
- SI
- Value:
- 1.21
- Test group / Remarks:
- 2.5% (w/w) in propylene glycol
- Key result
- Parameter:
- SI
- Value:
- 1.31
- Test group / Remarks:
- 5% (w/w) in propylene glycol
- Key result
- Parameter:
- SI
- Value:
- 1.03
- Test group / Remarks:
- 10% (w/w) in propylene glycol
- Cellular proliferation data / Observations:
- For individual results see Table 2 in box 'Any other information on results incl. tables'.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a local lymph node assay in mice, manganese oxide was tested negative for skin sensitisation.
- Executive summary:
In a dermal sensitisation study according to guideline OECD 429 with manganese oxide (77% Mn content) in propylene glycol, young adult female CBA/Ca mice (4/dose) were tested using the method of the Local Lymph Node Assay. The positive control, Phenylacetaldehyde (90%) in dimethyl formamide (vehicle) produced an increase in the stimulation index (SI) greater than 3 over the control groups. Concentrations of manganese oxide at 2.5, 5 and 10% w/w in propylene glycol did not produce a Stimulation Index greater than 1.31. Due to data showing a Stimulation Index of less than 3 in the study, manganese oxide is not a dermal sensitiser.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across statement (see IUCLID section 13).
Reference
Table 1: The Stimulation Index (positive control -Phenylacetaldehyde (90%) expressed as the mean radioactive incorporation for the positive control group divided by the mean radioactive incorporation of the vehicle control group
Concentration (% w/w) in Propylene glycol |
Stimulation Index |
Result |
2.5 |
4.20 |
Positive |
Table 2: Disintegrations per minute, disintegrations per minute/node and Stimulation Index
Concentration (% w/w) in propylene glycol |
dpm |
Dpm/Nodea |
Stimulation Indexb |
Result |
Vehicle |
3734.44 |
466.81 |
na |
na |
2.5 |
4535.63 |
566.95 |
1.21 |
Negative |
5 |
4876.24 |
609.53 |
1.31 |
Negative |
10 |
3853.15 |
481.64 |
1.03 |
Negative |
dpm = Disintegrations per minute
a = Disintegrations per minute/node obtained by dividing the disintegrations per minute value by 8 (total) number of lymph nodes)
b = Stimulation Index of 3.0 or greater indicates a positive result
na = Not applicable
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data is available for the target substance dimanganese trioxide. Thus, to assess the potential to induce skin sensitisation of the target substance, available data from manganese oxide (source substance) was used in read-across approach. The source substance was tested negative in an in vivo Local Lymph Node assay conducted in accordance with OECD test guideline 429. Based on this result, the target substance dimanganese trioxide is not considered to be a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on available data from a suitable read-across partner, dimanganese trioxide does not warrant classification for skin sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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