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Diss Factsheets
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EC number: 222-940-2 | CAS number: 3674-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin corrosion/irritation
Experimental data on the potential of skin corrosion/irritation are available for the substance.
The substance is resulted skin irritant during an acute toxicity study (skin irritation); vesicle formation are reported.
The following deepening for this property has been performed.
As a result of an overall assessment of the QSAR predictions (detailed in Table below) the substance can be classified for skin irritation.
|
Name of the software |
Model/module |
Model type |
Result |
Skin irritation |
QSAR Toolbox |
Skin irritation/corrosion Inclusion rules by BfR |
Structural alerts |
Aliphatic alpha-halogen-esters
Structural alerts associated with chemicals that can cause irritation.
Skin irritation potential, can be related to a combination of MW and log Pow, e.g., chemicals with MW < 200 and log Pow of > 2 had enhanced skin irritation potential.
For chemicals with MW < 200 skin corrosion potential is enhanced and appears to be independent of log Pow.
[Hulzebos E. et al. 2005]
MW: 156.99 log Pow: 1.3 [Predicted]
|
Danish (Q)SAR database |
Severe Skin Irritation in Rabbit |
Qualitative
|
Model results:
Battery POS_IN
CASE Ultra POS_OUT
Leadscope POS_IN
SciQSAR POS_IN
This results are considered reliable.
|
|
Toxtree |
Skin irritation/ skin corrosion |
Structural alerts |
Irritating to skin |
|
Abbreviations INC: inconclusive. A definite call within the defined applicability domain could not be made. NEG: negative POS: positive IN: inside applicability domain OUT: outside applicability domain |
Serious eye damage/eye irritation
Experimental data on this property are available.
The substance is resulted eye irritant during an acute toxicity study (eye irritation); vesicle formation are reported.
Classification provided by companies to ECHA in CLP notifications this substance causes eye damage.
Specific target organ toxicity - single
Vapours of the substance cause an irritation on the mucous membranes of the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Justification for classification or non-classification
Skin corrosion/irritation
Available data are deemed sufficient for classify the substance as Skin Irrit. 2; H315.
Serious eye damage/eye irritation
Available data are deemed sufficient for classify the substance as Eye Irrit. 2; H319.
Specific target organ toxicity - single
Overall, this data is deemed sufficient for classify the substance as STOT SE 3; H335.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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