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EC number: 270-315-8 | CAS number: 68424-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
- Endpoint:
- density, other
- Remarks:
- density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- other: Study report pertains to multiple endpoints.
Reference
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- > 32 - < 59 °C
- Atm. press.:
- 101 hPa
- Conclusions:
- The melting temperature of the test item has been determined to be over the range 32 to 59 °C (305 to 332 K).
- Executive summary:
The Melting/Freezing Point was determined to be over the range 32 to 59 °C (305 to 332 K), by differential scanning calorimetry, designed to be compatible with Method A.1 Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 102 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Temperature (°C) |
|||
Thermal Event |
Interpretation |
Determination 1 |
Determination 2 |
Endotherm |
Melting range |
31.91 to 58.81 |
32.00 to 58.86 |
The melting transition of the test item was considered to be softening over a broad range.
- Reason / purpose for cross-reference:
- other: Study report pertains to multiple endpoints.
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Atm. press.:
- 101 kPa
- Decomposition:
- yes
- Decomp. temp.:
- 155 °C
- Conclusions:
- The test item has been determined to decompose from approximately 155 °C (428 K) at 101 kPa. As the test item decomposed, no value for boiling temperature could be determined.
- Executive summary:
Decomposition from approximately 155 °C (428 K) at 101 kPa by differential scanning calorimetry, designed to be compatible with Method A.2 Boiling Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 103 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. As the test item decomposed, no value for boiling temperature could be determined.
Thermographic Data
Temperature (°C) |
|||
Thermal Event |
Interpretation |
Determination 1 |
Determination 2 |
Exotherm |
Approximate onset of decomposition |
154.66 |
160.83 |
Atmospheric pressure: 101 kPa
After heating to 400 °C, the samples had lost approximately 64% of their original weight.
Overall result: decomposition from approximately 155 °C (428 K)
As a result of the low rate of enthalpy change during decomposition, the onset temperature could only be approximated. Two further thermograms were run for additional information. These showed that after being heated to 150 °C and 300 °C they had lost none and 7% of their original weight respectively. The appearance of the residue after being heated to 150 °C was similar to that of the original test item; this also suggested that decomposition had not occurred up to 150 °C.
- Reason / purpose for cross-reference:
- other: Study report pertains to multiple endpoints.
Reference
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- ring method
- Key result
- Surface tension:
- > 70.8 - < 71.8 mN/m
- Temp.:
- 21.3 °C
- Conc.:
- 0.1 g/L
- Conclusions:
- The surface tension, of solutions prepared at nominally 0.1 g/L of test item in water and diluted to 90 % saturation, has been determined to be 71.3 mN/m at 21.3 ± 0.5 °C. The test item was considered to be not surface-active.
- Executive summary:
The surface tension of the test substance was determined to be 71.3 ± 0.5 mN/m at 21.3 ± 0.5 °C (for solutions prepared at nominally 0.1 g/L of test item in water and diluted to 90% saturation), using a ring method designed to be compatible with Method A5 Surface Tension of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 115 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The test item was considered to be not surface-active.
Readings, times and temperatures for the sample solutions:
SAMPLE 1:
Time (mins) |
Reading (mN/m) |
Temperature (°C) |
74 |
71.5 |
21 |
114 |
71.5 |
21.2 |
124 |
71.5 |
21.2 |
134 |
71.5 |
21.4 |
144 |
71.5 |
21.4 |
SAMPLE 2:
Time (mins) |
Reading (mN/m) |
Temperature (°C) |
246 |
71 |
21.4 |
256 |
71 |
21.4 |
266 |
71 |
21.4 |
276 |
71 |
21.6 |
286 |
71 |
21.6 |
Mean Sample 1 result : 71.5 mN/m
pH of Sample 1 : 5.8
Mean Sample 2 result : 71.0 mN/m
pH of Sample 2 : 5.6
Overall result : 71.3 ± 0.5 mN/m
Overall temperature : 21.3 ± 0.5 °C
- Reason / purpose for cross-reference:
- other: Study report pertains to multiple endpoints.
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 0.016 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 100 mg/L
- Incubation duration:
- 22 h
- Temp.:
- 20 °C
- pH:
- 5.9
- Details on results:
- Preliminary Test: The preliminary estimate of water solubility at 20.0 ± 0.5 °C was determined to be less than 2.86 x 10-2 g/L. The solution had a pH of 5.5.
Main Test: Overall concentration: less than 1.64E-02 g/L at 20.0 ± 0.5 °C - Conclusions:
- The water solubility of the test item has been determined to be less than 1.64E-02 g/L at 20.0 ± 0.5 °C based on selected components. It was considered that the water solubility of the test item as a whole would be less than 1E-03 g/L.
- Executive summary:
The water solubility of the test substance was less than 1.64E-02 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. It was considered that the water solubility of the test item as a whole would be less than 1E-03 g/L.
The concentration (g/L) of four test item components in the sample solutions at 20.0 ± 0.5 °C are shown in the following table:
Sample Number |
Time Shaken at ~ 30 °C (hours) |
Time Equilibrated at 20 °C (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
24 |
1.64E-02 |
5.9 |
2 |
48 |
24 |
1.40E-02 |
5.9 |
3 |
72 |
24 |
1.34E-02 |
5.9 |
- Reason / purpose for cross-reference:
- other: Study report pertains to multiple endpoints.
Reference
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 March 2016 to 20 July 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 10
- Temp.:
- 40 °C
- pH:
- 5.5
- Details on results:
- Overall log10 Pow: >10.0 Overall
Partition coefficient: >1.0E+10 - Conclusions:
- The partition coefficient of the test item has been determined to be >1.0E+10 with a log10 Pow of >10.0.
- Executive summary:
The Partition Coefficient (n-octanol/water) was determined to be greater than 1.0E+10, log10 Pow of >10.0, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
Partition coefficient of sample: The retention times, capacity factor and log10 Pow value determined for the sample:
Injection |
Retention Time (mins) |
Capacity Factor (k') |
Log10 k' |
Log10 Pow |
Mean Log10 Pow |
1 |
≥85.513 |
>58.6 |
>1.77 |
>10.0 |
>10 |
2 |
≥85.527 |
>58.6 |
>1.77 |
>10.0 |
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- pycnometer method
Test material
- Reference substance name:
- Lanolin, hydroxylated
- EC Number:
- 270-315-8
- EC Name:
- Lanolin, hydroxylated
- Cas Number:
- 68424-66-8
- IUPAC Name:
- Lanolin, hydroxylated
- Test material form:
- solid
Constituent 1
- Dynamic viscosity of test material:
- Due to the test item’s viscosity, it was considered that the pycnometer method for liquids would be impractical. Therefore, it was decided to melt and transfer the test item into glass vessels which would fit inside the sample cell of the gas comparison pycnometer. The samples were then equilibrated to 20 °C. Two determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.
Results and discussion
Densityopen allclose all
- Key result
- Type:
- density
- Density:
- 963 kg/m³
- Temp.:
- 20 °C
- Key result
- Type:
- relative density
- Density:
- 0.963
- Temp.:
- 20 °C
Any other information on results incl. tables
Mass of the vessel, vessel and test item, and the calculated mass of test item
Determination |
Mass of Vessel (g) |
Mass of Vessel and Test Item (g) |
Mass of Test Item (g) |
1 |
30.8952 |
67.049 |
36.1538 |
2 |
31.7775 |
69.9526 |
38.175 |
Pressure readings obtained for the vessel and vessel containing test item:
Determination |
Replicate |
Vessel |
Vessel and Test Item |
||||
P1(sample) (psig) |
P2(sample) (psig) |
Volume (cm³) |
P3(sample) (psig) |
P4(sample) (psig) |
Volume (cm³) |
||
1 |
A |
17.282 |
6.953 |
14.1 |
17.242 |
8.312 |
51.4 |
B |
17.262 |
6.942 |
14 |
17.265 |
8.332 |
51.6 |
|
C |
17.228 |
6.928 |
14 |
17.247 |
8.326 |
51.7 |
|
2 |
A |
17.237 |
6.945 |
14.4 |
17.23 |
8.423 |
54.1 |
B |
17.339 |
6.986 |
14.4 |
17.195 |
8.405 |
54 |
|
C |
17.208 |
6.933 |
14.4 |
17.296 |
8.454 |
54 |
Calculated volumes and density:
Determination |
Mean Volume of Vessel (cm³) |
Mean Volume of Vessel and Test Item (cm³) |
Volume of Test Item (cm³) |
Density (kg/m³) |
1 |
14 |
51.6 |
37.6 |
963 |
2 |
14.4 |
54 |
39.6 |
964 |
Relative density : 0.963
Temperature : 20.0 ± 1.0°C
Applicant's summary and conclusion
- Conclusions:
- The density of the test item has been determined to be 963 kg/m³ at 20.0 ± 1.0 °C and a relative density of 0.963.
- Executive summary:
The test substance density was determined to be 963 kg/m³ at 20.0 ± 1.0 °C and a relative density of 0.963, by gas comparison pycnometer, designed to be compatible with Method A.3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.
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